1LW6

Crystal Structure of the Complex of Subtilisin BPN' with Chymotrypsin Inhibitor 2 at 1.5 Angstrom Resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis
E	0008236	molecular_function	serine-type peptidase activity
I	0004867	molecular_function	serine-type endopeptidase inhibitor activity
I	0009611	biological_process	response to wounding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 300

Chain	Residue
E	GLN2
E	ASP41
E	LEU75
E	ASN77
E	ILE79
E	VAL81

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 E 602

Chain	Residue
E	HIS278
E	HIS279
E	HIS280
E	HIS281
E	HOH734
E	HOH754
E	SER248
E	ASN252
E	HIS276

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 603

Chain	Residue
E	THR253
E	HIS276
E	HIS277
E	HOH684
E	HOH995
E	HOH996

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 E 604

Chain	Residue
E	GLN103
E	TYR104
E	SER105
E	SER159
E	GLY160
E	HOH835
E	HOH990
E	HOH1008
I	HOH87

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 605

Chain	Residue
E	SER18
E	HIS281
E	HOH655
E	HOH741
E	HOH966

---

Functional Information from PROSITE/UniProt

site_id	PS00136
Number of Residues	12
Details	SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VAVIDSGIdssH

Chain	Residue	Details
E	VAL28-HIS39

---

site_id	PS00137
Number of Residues	11
Details	SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGThVAGtVAA

Chain	Residue	Details
E	HIS64-ALA74

---

site_id	PS00138
Number of Residues	11
Details	SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSmAsPhVAG

Chain	Residue	Details
E	GLY219-GLY229

---

site_id	PS00285
Number of Residues	12
Details	POTATO_INHIBITOR Potato inhibitor I family signature. WPELVGksVeeA

Chain	Residue	Details
I	TRP24-ALA35

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Reactive bond

Chain	Residue	Details
I	GLU60
E	HIS64
E	SER221

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING:

Chain	Residue	Details
E	GLN2
E	ASP41
E	LEU75
E	ASN77
E	ILE79
E	VAL81
E	GLY169
E	TYR171
E	VAL174

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1sca

Chain	Residue	Details
E	SER221
E	HIS64
E	ASP32

---

site_id	MCSA1
Number of Residues	4
Details	M-CSA 723

Chain

Residue

Details

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