1LW4
X-ray structure of L-Threonine Aldolase (low-specificity) in complex with L-allo-threonine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006545 | biological_process | glycine biosynthetic process |
| A | 0006567 | biological_process | threonine catabolic process |
| A | 0008732 | molecular_function | L-allo-threonine aldolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006545 | biological_process | glycine biosynthetic process |
| B | 0006567 | biological_process | threonine catabolic process |
| B | 0008732 | molecular_function | L-allo-threonine aldolase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006545 | biological_process | glycine biosynthetic process |
| C | 0006567 | biological_process | threonine catabolic process |
| C | 0008732 | molecular_function | L-allo-threonine aldolase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0006545 | biological_process | glycine biosynthetic process |
| D | 0006567 | biological_process | threonine catabolic process |
| D | 0008732 | molecular_function | L-allo-threonine aldolase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 1054 |
| Chain | Residue |
| B | THR8 |
| B | THR10 |
| B | SER198 |
| B | ALA203 |
| C | GLN232 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA D 1055 |
| Chain | Residue |
| D | GLN232 |
| A | THR8 |
| A | THR10 |
| A | SER198 |
| A | ALA203 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 1056 |
| Chain | Residue |
| A | GLN232 |
| D | THR10 |
| D | SER198 |
| D | ALA203 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 1057 |
| Chain | Residue |
| B | GLN232 |
| C | THR8 |
| C | THR10 |
| C | SER198 |
| C | ALA203 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1058 |
| Chain | Residue |
| B | ASN326 |
| B | GLU329 |
| B | HOH1138 |
| B | HOH1278 |
| B | HOH1279 |
| B | HOH1280 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA D 1059 |
| Chain | Residue |
| D | ASN326 |
| D | GLU329 |
| D | HOH1305 |
| D | HOH1306 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1060 |
| Chain | Residue |
| B | HOH1193 |
| A | HOH1204 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 1061 |
| Chain | Residue |
| D | HOH1135 |
| C | HOH1163 |
| site_id | BC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PLP B 1053 |
| Chain | Residue |
| B | GLY58 |
| B | THR59 |
| B | GLU135 |
| B | ASP168 |
| B | ALA170 |
| B | ARG171 |
| B | LLP199 |
| C | ARG231 |
| B | HOH1110 |
| C | HOH1107 |
| B | HOH1141 |
| B | HOH1143 |
| B | HOH1185 |
| site_id | BC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE TLP B 1050 |
| Chain | Residue |
| B | SER6 |
| B | GLY58 |
| B | THR59 |
| B | HIS83 |
| B | ASP168 |
| B | ALA170 |
| B | ARG171 |
| B | LLP199 |
| B | ARG316 |
| C | ARG231 |
| D | HIS125 |
| B | HOH1110 |
| C | HOH1107 |
| B | HOH1141 |
| B | HOH1143 |
| C | HOH1139 |
| C | HOH1161 |
| B | HOH1185 |
| site_id | BC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE TLP C 1051 |
| Chain | Residue |
| B | ARG231 |
| C | SER6 |
| C | GLY58 |
| C | THR59 |
| C | HIS83 |
| C | GLU135 |
| C | ASP168 |
| C | ARG171 |
| C | LLP199 |
| C | ARG316 |
| C | HOH1072 |
| B | HOH1082 |
| A | HOH1076 |
| C | HOH1078 |
| C | HOH1086 |
| C | HOH1105 |
| C | HOH1144 |
| C | HOH1193 |
| site_id | BC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE TLP D 1052 |
| Chain | Residue |
| D | HOH1304 |
| A | ARG231 |
| D | SER6 |
| D | GLY58 |
| D | THR59 |
| D | HIS83 |
| D | GLU135 |
| D | ASP168 |
| D | ALA170 |
| D | ARG171 |
| D | LLP199 |
| D | ARG316 |
| D | HOH1127 |
| B | HOH1134 |
| D | HOH1155 |
| D | HOH1160 |
| D | HOH1178 |
| D | HOH1220 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | TYR30 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | HIS83 | |
| B | ASP168 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | HIS83 | |
| C | ASP168 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | HIS83 | |
| D | ASP168 |
| site_id | CSA13 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | GLU135 | |
| A | HIS83 | |
| A | ASP168 |
| site_id | CSA14 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | GLU135 | |
| B | HIS83 | |
| B | ASP168 |
| site_id | CSA15 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | GLU135 | |
| C | HIS83 | |
| C | ASP168 |
| site_id | CSA16 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | GLU135 | |
| D | HIS83 | |
| D | ASP168 |
| site_id | CSA17 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | PHE85 | |
| A | ASP168 |
| site_id | CSA18 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | PHE85 | |
| B | ASP168 |
| site_id | CSA19 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | PHE85 | |
| C | ASP168 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | TYR30 |
| site_id | CSA20 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | PHE85 | |
| D | ASP168 |
| site_id | CSA21 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | GLU32 |
| site_id | CSA22 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | GLU32 |
| site_id | CSA23 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | GLU32 |
| site_id | CSA24 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | GLU32 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | TYR30 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | TYR30 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | TRP86 | |
| A | ASP168 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | TRP86 | |
| B | ASP168 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | TRP86 | |
| C | ASP168 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | TRP86 | |
| D | ASP168 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | HIS83 | |
| A | ASP168 |
