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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1LVO

Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008233	molecular_function	peptidase activity
A	0019082	biological_process	viral protein processing
B	0008233	molecular_function	peptidase activity
B	0019082	biological_process	viral protein processing
C	0008233	molecular_function	peptidase activity
C	0019082	biological_process	viral protein processing
D	0008233	molecular_function	peptidase activity
D	0019082	biological_process	viral protein processing
E	0008233	molecular_function	peptidase activity
E	0019082	biological_process	viral protein processing
F	0008233	molecular_function	peptidase activity
F	0019082	biological_process	viral protein processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 3001

Chain	Residue
C	GLU179

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 3002

Chain	Residue
C	ARG130
C	ASN196

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 3003

Chain	Residue
A	ASN168
A	LEU192
A	GLU193
A	GLY194
A	HOH4029

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 3004

Chain	Residue
A	LYS136
A	ASN196
A	HOH4135
A	ARG130

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 3005

Chain	Residue
C	ASN168
C	LEU192
C	GLU193
C	GLY194
C	HOH4077

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 3006

Chain	Residue
B	ASN168
B	GLU193
B	GLY194
B	HOH4075
B	HOH4158

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 3007

Chain	Residue
B	HOH4178
E	ASN168
E	LEU192
E	GLU193
E	GLY194

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 3008

Chain	Residue
D	ARG130
D	ASN196
D	HOH4083

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 3009

Chain	Residue
E	ARG130
E	HOH4100
E	HOH4184
E	HOH4210

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 3010

Chain	Residue
F	ASN168
F	LEU192
F	GLU193
F	GLY194

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 3011

Chain	Residue
A	GLY214
A	GLU215
A	ARG216
A	TRP217

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 3012

Chain	Residue
D	ASN168
D	LEU192
D	GLU193
D	GLY194
D	HOH4026

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 3013

Chain	Residue
E	ARG275
E	THR276
E	HOH4094

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 3015

Chain	Residue
C	ARG275
C	THR276

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 3016

Chain	Residue
D	GLY214
D	ARG216
D	TRP217
D	HOH4168

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 3017

Chain	Residue
D	ARG275
D	THR276

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 3018

Chain	Residue
E	VAL60
E	ARG61
E	LEU62
E	HIS63

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 3019

Chain	Residue
F	ARG216
F	TRP217
F	DIO2003

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 3020

Chain	Residue
B	LYS82
B	PHE102
B	PHE176

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 3021

Chain	Residue
C	ARG294
D	ALA115
D	SER123

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 3022

Chain	Residue
A	LYS103
A	SER104

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 3023

Chain	Residue
C	GLY214
C	GLU215
C	ARG216
C	TRP217
C	ARG275
C	HOH4035

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 3024

Chain	Residue
F	ARG61
F	LEU62
F	HIS63

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 3025

Chain	Residue
F	ARG130
F	LYS136
F	ASN196

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 3026

Chain	Residue
B	ARG19
B	SER21
B	HOH4070
B	HOH4116

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 3027

Chain	Residue
A	ARG19
A	SER21
A	VAL26

site_id	CC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DIO E 2001

Chain	Residue
B	GLY273
E	ARG216
E	TRP217
E	HOH4063
E	HOH4132
E	HOH4229
E	HOH4230

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DIO E 2002

Chain	Residue
E	SER123
E	HOH4185
F	MET6

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DIO F 2003

Chain	Residue
F	GLY274
F	ARG275
F	THR276
F	SO43019

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DIO A 2004

Chain	Residue
A	ASN112
A	GLU291

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DIO A 2005

Chain	Residue
A	SER131
A	GLN132
A	GLY133

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DIO A 2006

Chain	Residue
A	GLY122
A	SER123
A	HOH4112

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DIO B 2007

Chain	Residue
B	PHE139
B	CYS144
B	HIS162
B	GLU165

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DIO C 2008

Chain	Residue
C	SER223
C	MET224
C	SER225
C	SER228

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DIO C 2009

Chain	Residue
C	LYS136
C	HOH4124
D	GLY2
D	ASN213

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD A 4001

Chain	Residue
A	HIS41
A	HIS163
A	LEU164
A	GLN187
A	PRO188

site_id	EC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MRD B 4002

Chain	Residue
B	HIS41
B	THR47
B	ILE51
B	TYR53
B	LEU164
B	ASP186
B	HOH4192

site_id	EC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MRD C 4003

Chain	Residue
C	HIS41
C	THR47
C	ILE51
C	TYR53
C	LEU164
C	ASP186

site_id	EC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MRD D 4004

Chain	Residue
D	HIS41
D	ILE51
D	TYR53
D	LEU164
D	ASP186
D	GLN187
D	PRO188

site_id	EC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MRD E 4005

Chain	Residue
E	HIS41
E	THR47
E	HIS163
E	LEU164
E	ASP186
E	GLN187
E	HOH4045

site_id	EC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD F 4006

Chain	Residue
F	HIS41
F	THR47
F	ASP186
F	GLN187
F	PRO188

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"For 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 2bx4

Chain	Residue	Details
A	CYS144
A	HIS41

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 2bx4

Chain	Residue	Details
B	CYS144
B	HIS41

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 2bx4

Chain	Residue	Details
C	CYS144
C	HIS41

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 2bx4

Chain	Residue	Details
D	CYS144
D	HIS41

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 2bx4

Chain	Residue	Details
E	CYS144
E	HIS41

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 2bx4

Chain	Residue	Details
F	CYS144
F	HIS41

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