1LUW
CATALYTIC AND STRUCTURAL EFFECTS OF AMINO-ACID SUBSTITUTION AT HIS 30 IN HUMAN MANGANESE SUPEROXIDE DISMUTASE: INSERTION OF VAL CGAMMA INTO THE SUBSTRATE ACCESS CHANNEL
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004784 | molecular_function | superoxide dismutase activity |
| A | 0006801 | biological_process | superoxide metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004784 | molecular_function | superoxide dismutase activity |
| B | 0006801 | biological_process | superoxide metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 800 |
| Chain | Residue |
| A | HIS26 |
| A | HIS74 |
| A | ASP159 |
| A | HIS163 |
| A | HOH199 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 801 |
| Chain | Residue |
| B | HOH200 |
| B | HIS26 |
| B | HIS74 |
| B | ASP159 |
| B | HIS163 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 898 |
| Chain | Residue |
| A | HIS2 |
| A | SER3 |
| A | HIS71 |
| B | LYS178 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 899 |
| Chain | Residue |
| B | HIS2 |
| B | SER3 |
| B | HIS71 |
Functional Information from PROSITE/UniProt
| site_id | PS00088 |
| Number of Residues | 8 |
| Details | SOD_MN Manganese and iron superoxide dismutases signature. DvWEHAYY |
| Chain | Residue | Details |
| A | ASP159-TYR166 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10852710","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11580280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1394426","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19265433","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9537987","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9537988","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JA8","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1AP5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1AP6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EM1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N0J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZSP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZTE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZUQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2P4K","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"PubMed","id":"10334867","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16399855","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P09671","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P09671","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
