1LUA
Structure of methylene-tetrahydromethanopterin dehydrogenase from Methylobacterium extorquens AM1 complexed with NADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046294 | biological_process | formaldehyde catabolic process |
| B | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046294 | biological_process | formaldehyde catabolic process |
| C | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0046294 | biological_process | formaldehyde catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAP A 456 |
| Chain | Residue |
| A | ASN97 |
| A | LYS156 |
| A | ALA196 |
| A | GLY197 |
| A | ALA198 |
| A | ILE199 |
| A | LEU201 |
| A | TYR221 |
| A | ASN222 |
| A | LYS256 |
| A | HOH3270 |
| A | THR102 |
| A | HOH3395 |
| A | HOH3456 |
| A | HOH3474 |
| A | HOH3515 |
| A | HOH3644 |
| A | HOH3687 |
| A | HOH3813 |
| A | HOH3875 |
| A | HOH3893 |
| A | ALA127 |
| A | THR129 |
| A | GLY130 |
| A | PRO131 |
| A | VAL132 |
| A | GLY151 |
| A | ARG152 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NAP B 1456 |
| Chain | Residue |
| B | ASN97 |
| B | THR102 |
| B | THR129 |
| B | GLY130 |
| B | PRO131 |
| B | VAL132 |
| B | GLY151 |
| B | ARG152 |
| B | LYS156 |
| B | ALA196 |
| B | GLY197 |
| B | ALA198 |
| B | ILE199 |
| B | LEU201 |
| B | TYR221 |
| B | ASN222 |
| B | LYS256 |
| B | HOH3352 |
| B | HOH3537 |
| B | HOH3579 |
| B | HOH3684 |
| B | HOH3696 |
| B | HOH3896 |
| site_id | AC3 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAP C 2456 |
| Chain | Residue |
| C | ASN97 |
| C | THR102 |
| C | ALA127 |
| C | THR129 |
| C | GLY130 |
| C | PRO131 |
| C | VAL132 |
| C | GLY151 |
| C | ARG152 |
| C | LYS156 |
| C | ALA196 |
| C | GLY197 |
| C | ALA198 |
| C | ILE199 |
| C | LEU201 |
| C | TYR221 |
| C | ASN222 |
| C | LYS256 |
| C | HOH3243 |
| C | HOH3433 |
| C | HOH3445 |
| C | HOH3603 |
| C | HOH3646 |
| C | HOH3709 |
| C | HOH3731 |
| C | HOH3764 |
| C | HOH3766 |
| C | HOH3842 |
| C | HOH3855 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11297742 |
| Chain | Residue | Details |
| A | GLY130 | |
| C | LYS153 | |
| C | ALA196 | |
| C | LEU257 | |
| A | LYS153 | |
| A | ALA196 | |
| A | LEU257 | |
| B | GLY130 | |
| B | LYS153 | |
| B | ALA196 | |
| B | LEU257 | |
| C | GLY130 |
