1LT7

Oxidized Homo sapiens betaine-homocysteine S-methyltransferase in complex with four Sm(III) ions

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006479	biological_process	protein methylation
A	0006577	biological_process	amino-acid betaine metabolic process
A	0006579	biological_process	amino-acid betaine catabolic process
A	0008168	molecular_function	methyltransferase activity
A	0008172	molecular_function	S-methyltransferase activity
A	0008270	molecular_function	zinc ion binding
A	0009086	biological_process	methionine biosynthetic process
A	0032259	biological_process	methylation
A	0046500	biological_process	S-adenosylmethionine metabolic process
A	0046872	molecular_function	metal ion binding
A	0047150	molecular_function	betaine-homocysteine S-methyltransferase activity
A	0050666	biological_process	regulation of homocysteine metabolic process
A	0070062	cellular_component	extracellular exosome
A	0071266	biological_process	'de novo' L-methionine biosynthetic process
A	0071267	biological_process	L-methionine salvage
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006479	biological_process	protein methylation
B	0006577	biological_process	amino-acid betaine metabolic process
B	0006579	biological_process	amino-acid betaine catabolic process
B	0008168	molecular_function	methyltransferase activity
B	0008172	molecular_function	S-methyltransferase activity
B	0008270	molecular_function	zinc ion binding
B	0009086	biological_process	methionine biosynthetic process
B	0032259	biological_process	methylation
B	0046500	biological_process	S-adenosylmethionine metabolic process
B	0046872	molecular_function	metal ion binding
B	0047150	molecular_function	betaine-homocysteine S-methyltransferase activity
B	0050666	biological_process	regulation of homocysteine metabolic process
B	0070062	cellular_component	extracellular exosome
B	0071266	biological_process	'de novo' L-methionine biosynthetic process
B	0071267	biological_process	L-methionine salvage

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SM A 501

Chain	Residue
A	CIT601
A	HOH618
A	HOH646

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SM B 502

Chain	Residue
A	HOH694
B	HOH702

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site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SM A 503

Chain	Residue
A	HOH749

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SM B 504

Chain	Residue
B	CIT602

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site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CIT A 601

Chain	Residue
A	ARG356
A	SM501
A	HOH615
A	HOH641
A	HOH646
B	TYR363
B	LYS369
A	HIS252
A	LYS283

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site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CIT B 602

Chain	Residue
A	GLY360
A	PRO362
A	TYR363
B	ASP220
B	HIS252
B	ARG356
B	SM504
B	HOH606
B	HOH639

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00333, ECO:0000269|PubMed:12220488, ECO:0007744|PDB:1LT8

Chain	Residue	Details
A	CYS217
A	CYS299
A	CYS300
B	CYS217
B	CYS299
B	CYS300

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site_id	SWS_FT_FI2
Number of Residues	12
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:O35490

Chain	Residue	Details
A	LYS40
B	LYS241
B	LYS340
B	LYS377
A	LYS93
A	LYS232
A	LYS241
A	LYS340
A	LYS377
B	LYS40
B	LYS93
B	LYS232

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O09171

Chain	Residue	Details
A	SER330
B	SER330

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