1LT7
Oxidized Homo sapiens betaine-homocysteine S-methyltransferase in complex with four Sm(III) ions
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006577 | biological_process | amino-acid betaine metabolic process |
| A | 0006579 | biological_process | amino-acid betaine catabolic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008172 | molecular_function | S-methyltransferase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0046500 | biological_process | S-adenosylmethionine metabolic process |
| A | 0047150 | molecular_function | betaine-homocysteine S-methyltransferase activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
| A | 0071267 | biological_process | L-methionine salvage |
| B | 0005634 | cellular_component | nucleus |
| B | 0005829 | cellular_component | cytosol |
| B | 0006577 | biological_process | amino-acid betaine metabolic process |
| B | 0006579 | biological_process | amino-acid betaine catabolic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008172 | molecular_function | S-methyltransferase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0046500 | biological_process | S-adenosylmethionine metabolic process |
| B | 0047150 | molecular_function | betaine-homocysteine S-methyltransferase activity |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
| B | 0071267 | biological_process | L-methionine salvage |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SM A 501 |
| Chain | Residue |
| A | CIT601 |
| A | HOH618 |
| A | HOH646 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SM B 502 |
| Chain | Residue |
| A | HOH694 |
| B | HOH702 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SM A 503 |
| Chain | Residue |
| A | HOH749 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SM B 504 |
| Chain | Residue |
| B | CIT602 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CIT A 601 |
| Chain | Residue |
| A | ARG356 |
| A | SM501 |
| A | HOH615 |
| A | HOH641 |
| A | HOH646 |
| B | TYR363 |
| B | LYS369 |
| A | HIS252 |
| A | LYS283 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CIT B 602 |
| Chain | Residue |
| A | GLY360 |
| A | PRO362 |
| A | TYR363 |
| B | ASP220 |
| B | HIS252 |
| B | ARG356 |
| B | SM504 |
| B | HOH606 |
| B | HOH639 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00333","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12220488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LT8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"O35490","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
