1LQM

ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE COMPLEX WITH URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004844	molecular_function	uracil DNA N-glycosylase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006974	biological_process	DNA damage response
A	0016787	molecular_function	hydrolase activity
A	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
A	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
B	0005515	molecular_function	protein binding
C	0004844	molecular_function	uracil DNA N-glycosylase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006281	biological_process	DNA repair
C	0006284	biological_process	base-excision repair
C	0006974	biological_process	DNA damage response
C	0016787	molecular_function	hydrolase activity
C	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
C	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
D	0005515	molecular_function	protein binding
E	0004844	molecular_function	uracil DNA N-glycosylase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0006281	biological_process	DNA repair
E	0006284	biological_process	base-excision repair
E	0006974	biological_process	DNA damage response
E	0016787	molecular_function	hydrolase activity
E	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
E	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
F	0005515	molecular_function	protein binding
G	0004844	molecular_function	uracil DNA N-glycosylase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0006281	biological_process	DNA repair
G	0006284	biological_process	base-excision repair
G	0006974	biological_process	DNA damage response
G	0016787	molecular_function	hydrolase activity
G	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
G	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
H	0005515	molecular_function	protein binding

Functional Information from PROSITE/UniProt

site_id	PS00130
Number of Residues	10
Details	U_DNA_GLYCOSYLASE Uracil-DNA glycosylase signature. KVVIlGQDPY

Chain	Residue	Details
A	LYS57-TYR66

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1eug

Chain	Residue	Details
A	HIS187
A	ASP64

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1eug

Chain	Residue	Details
C	HIS187
C	ASP64

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site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1eug

Chain	Residue	Details
E	HIS187
E	ASP64

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site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1eug

Chain	Residue	Details
G	HIS187
G	ASP64

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 71

Chain	Residue	Details
A	ASP64	activator, electrostatic stabiliser, increase acidity, proton acceptor, proton donor
A	TYR66	activator, steric role
A	PHE77	activator, steric role
A	HIS187	covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor

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site_id	MCSA2
Number of Residues	4
Details	M-CSA 71

Chain	Residue	Details
C	ASP64	activator, electrostatic stabiliser, increase acidity, proton acceptor, proton donor
C	TYR66	activator, steric role
C	PHE77	activator, steric role
C	HIS187	covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor

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site_id	MCSA3
Number of Residues	4
Details	M-CSA 71

Chain	Residue	Details
E	ASP64	activator, electrostatic stabiliser, increase acidity, proton acceptor, proton donor
E	TYR66	activator, steric role
E	PHE77	activator, steric role
E	HIS187	covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor

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site_id	MCSA4
Number of Residues	4
Details	M-CSA 71

Chain	Residue	Details
G	ASP64	activator, electrostatic stabiliser, increase acidity, proton acceptor, proton donor
G	TYR66	activator, steric role
G	PHE77	activator, steric role
G	HIS187	covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor

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