1LQM

ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE COMPLEX WITH URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004844	molecular_function	uracil DNA N-glycosylase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0016787	molecular_function	hydrolase activity
A	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
A	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
B	0005515	molecular_function	protein binding
C	0004844	molecular_function	uracil DNA N-glycosylase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006281	biological_process	DNA repair
C	0006284	biological_process	base-excision repair
C	0016787	molecular_function	hydrolase activity
C	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
C	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
D	0005515	molecular_function	protein binding
E	0004844	molecular_function	uracil DNA N-glycosylase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0006281	biological_process	DNA repair
E	0006284	biological_process	base-excision repair
E	0016787	molecular_function	hydrolase activity
E	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
E	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
F	0005515	molecular_function	protein binding
G	0004844	molecular_function	uracil DNA N-glycosylase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0006281	biological_process	DNA repair
G	0006284	biological_process	base-excision repair
G	0016787	molecular_function	hydrolase activity
G	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
G	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
H	0005515	molecular_function	protein binding

Functional Information from PROSITE/UniProt

site_id	PS00130
Number of Residues	10
Details	U_DNA_GLYCOSYLASE Uracil-DNA glycosylase signature. KVVIlGQDPY

Chain	Residue	Details
A	LYS57-TYR66

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	PRO65
C	PRO65
E	PRO65
G	PRO65

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1eug

Chain	Residue	Details
A	HIS187
A	ASP64

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1eug

Chain	Residue	Details
C	HIS187
C	ASP64

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1eug

Chain	Residue	Details
E	HIS187
E	ASP64

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1eug

Chain	Residue	Details
G	HIS187
G	ASP64

---

site_id	MCSA1
Number of Residues	4
Details	M-CSA 71

Chain	Residue	Details
A	PRO65	activator, electrostatic stabiliser, increase acidity, proton acceptor, proton donor
A	HIS67	activator, steric role
A	SER78	activator, steric role
A	PRO188	covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 71

Chain	Residue	Details
C	PRO65	activator, electrostatic stabiliser, increase acidity, proton acceptor, proton donor
C	HIS67	activator, steric role
C	SER78	activator, steric role
C	PRO188	covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA3
Number of Residues	4
Details	M-CSA 71

Chain	Residue	Details
E	PRO65	activator, electrostatic stabiliser, increase acidity, proton acceptor, proton donor
E	HIS67	activator, steric role
E	SER78	activator, steric role
E	PRO188	covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA4
Number of Residues	4
Details	M-CSA 71

Chain	Residue	Details
G	PRO65	activator, electrostatic stabiliser, increase acidity, proton acceptor, proton donor
G	HIS67	activator, steric role
G	SER78	activator, steric role
G	PRO188	covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor

---