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1LOQ

Crystal structure of orotidine monophosphate decarboxylase complexed with product UMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004590molecular_functionorotidine-5'-phosphate decarboxylase activity
A0005829cellular_componentcytosol
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006221biological_processpyrimidine nucleotide biosynthetic process
A0016831molecular_functioncarboxy-lyase activity
A0044205biological_process'de novo' UMP biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE U5P A 2001
ChainResidue
AASP20
APRO180
AGLN185
AGLY202
AARG203
AHOH3006
AHOH3009
AHOH3011
AHOH3012
AHOH3013
AHOH3014
ALYS42
AASP70
ALYS72
AASP75
AILE76
ATHR79
AMET126
ASER127

Functional Information from PROSITE/UniProt
site_idPS00156
Number of Residues14
DetailsOMPDECASE Orotidine 5'-phosphate decarboxylase active site. IIaDfKvaDIPeTN
ChainResidueDetails
AILE67-ASN80

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor
ChainResidueDetails
ALYS72

site_idSWS_FT_FI2
Number of Residues7
DetailsBINDING:
ChainResidueDetails
AASP20
ALYS42
AASP70
ASER127
APRO180
AGLY202
AARG203

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1dbt
ChainResidueDetails
ALYS72
AASP70

site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 1dbt
ChainResidueDetails
ALYS42
AASP75
ALYS72
AASP70

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PDB entries from 2024-11-13

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