1LO1

ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 195

Chain	Residue
A	CYS103
A	CYS106
A	CYS120
A	CYS123

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 196

Chain	Residue
A	CYS139
A	CYS145
A	CYS155
A	CYS158

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Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. ClvCg.Diasgy.HYgvasCeaCkaFFkR

Chain	Residue	Details
A	CYS103-ARG129

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	86
Details	DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
A	LYS100-LYS186

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site_id	SWS_FT_FI2
Number of Residues	44
Details	ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
A	CYS103-CYS123
A	CYS139-ALA163

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Important for stabilizing DNA-binding

Chain	Residue	Details
A	TYR185

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