1LNE

A STRUCTURAL ANALYSIS OF METAL SUBSTITUTIONS IN THERMOLYSIN

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004222	molecular_function	metalloendopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE VAL E 1321

Chain	Residue
E	ARG203
E	HIS231
E	HOH1059
E	LYS1322
E	ASN112
E	ALA113
E	GLU143

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LYS E 1322

Chain	Residue
E	ASN111
E	ASN112
E	PHE130
E	HIS231
E	HOH1059
E	VAL1321

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD E 900

Chain	Residue
E	HIS142
E	GLU143
E	HIS146
E	GLU166
E	HOH907
E	HOH1059

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 901

Chain	Residue
E	ASP138
E	GLU177
E	ASP185
E	GLU187
E	GLU190
E	HOH924

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site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD E 902

Chain	Residue
E	GLU177
E	ASN183
E	ASP185
E	GLU190
E	HOH931
E	HOH981

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site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD E 903

Chain	Residue
E	ASP57
E	ASP59
E	GLN61
E	HOH908
E	HOH910
E	HOH911

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site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 904

Chain	Residue
E	TYR193
E	THR194
E	ILE197
E	ASP200
E	HOH909
E	HOH932

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site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CD E 905

Chain	Residue
E	ASP213
E	HIS231
E	HOH1055
E	HOH1056
E	HOH1057

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site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS E 320

Chain	Residue
E	TYR66
E	TYR251

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site_id	CD0
Number of Residues	6
Details

Chain	Residue
E	GLU166
E	HIS142
E	GLU143
E	HIS146
E	HOH907
E	HOH1059

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV

Chain	Residue	Details
E	VAL139-VAL148

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
E	VAL289
E	SER291
E	THR293

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 176

Chain

Residue

Details

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