1LNC

A STRUCTURAL ANALYSIS OF METAL SUBSTITUTIONS IN THERMOLYSIN

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004222	molecular_function	metalloendopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE VAL E 1321

Chain	Residue
E	HIS231
E	HOH389
E	HOH906
E	HOH907
E	LYS1322
E	ASN112
E	ALA113
E	GLU143
E	ARG203

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LYS E 1322

Chain	Residue
E	ASN111
E	ASN112
E	VAL1321

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 900

Chain	Residue
E	HIS142
E	GLU143
E	HIS146
E	GLU166
E	HOH906
E	HOH907

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA E 901

Chain	Residue
E	ASP138
E	GLU177
E	ASP185
E	GLU187
E	GLU190
E	MN902
E	HOH926

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN E 902

Chain	Residue
E	GLU177
E	ASN183
E	ASP185
E	GLU190
E	CA901
E	HOH905
E	HOH909

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 903

Chain	Residue
E	ASP57
E	ASP59
E	GLN61
E	HOH908
E	HOH911
E	HOH912

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 904

Chain	Residue
E	TYR193
E	THR194
E	ILE197
E	ASP200
E	HOH910
E	HOH933

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS E 320

Chain	Residue
E	SER218
E	TYR251
E	HOH999

---

site_id	MN0
Number of Residues	5
Details

Chain	Residue
E	GLU166
E	HIS142
E	HIS146
E	HOH906
E	HOH907

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV

Chain	Residue	Details
E	VAL139-VAL148

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4808703","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4808703","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1tlp

Chain	Residue	Details
E	HIS231
E	GLU143

---

site_id	MCSA1
Number of Residues	7
Details	M-CSA 176

Chain

Residue

Details

---