1LML

LEISHMANOLYSIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0007155	biological_process	cell adhesion
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 578

Chain	Residue
A	GLU265
A	HIS268
A	HIS334
A	HOH663
A	HIS264

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site_id	ACT
Number of Residues	5
Details	ACTIVE SITE.

Chain	Residue
A	HIS264
A	GLU265
A	HIS268
A	HIS334
A	MET345

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site_id	CA1
Number of Residues	1
Details	CARBOHYDRATE BINDING SITE.

Chain	Residue
A	ASN300

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site_id	CA2
Number of Residues	1
Details	CARBOHYDRATE BINDING SITE.

Chain	Residue
A	ASN407

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site_id	CA3
Number of Residues	1
Details	CARBOHYDRATE BINDING SITE.

Chain	Residue
A	ASN534

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVTHEMAHAL

Chain	Residue	Details
A	VAL261-LEU270

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:9739094

Chain	Residue	Details
A	GLU265

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:9739094

Chain	Residue	Details
A	HIS264
A	HIS268
A	HIS334

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site_id	SWS_FT_FI3
Number of Residues	1
Details	LIPID: GPI-anchor amidated asparagine => ECO:0000269|PubMed:2145267

Chain	Residue	Details
A	ASN577

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:7675788, ECO:0000269|PubMed:9041519

Chain	Residue	Details
A	ASN300
A	ASN407

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:7675788

Chain	Residue	Details
A	ASN534

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	a catalytic site defined by CSA, PubMed 8519803, 9739094

Chain	Residue	Details
A	GLU265

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 668

Chain	Residue	Details
A	HIS264	metal ligand
A	GLU265	proton shuttle (general acid/base)
A	HIS268	metal ligand
A	HIS334	metal ligand

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