1LJL

Wild Type pI258 S. aureus arsenate reductase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0005737	cellular_component	cytoplasm
A	0030612	molecular_function	arsenate reductase (thioredoxin) activity
A	0046685	biological_process	response to arsenic-containing substance

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 133

Chain	Residue
A	ASN13
A	SER36
A	THR63
A	ASP65
A	HOH136
A	HOH143

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_01624","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11573087","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"12072565","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11573087","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12072565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12682056","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15159594","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16797027","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	11
Details	a catalytic site defined by CSA, PubMed 12072565, 8885840

Chain	Residue	Details
A	ASN13
A	ARG16
A	ARG16
A	SER17
A	SER17
A	CYS82
A	ASP105
A	GLY12
A	CYS89
A	CYS10
A	SER14

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site_id	MCSA1
Number of Residues	14
Details	M-CSA 143

Chain	Residue	Details
A	CYS10	electrofuge, electrophile, nucleofuge, nucleophile
A	THR63
A	ASP65
A	CYS82	electrofuge, electrophile, hydrogen bond acceptor, nucleofuge, nucleophile
A	CYS89	hydrogen bond acceptor, nucleofuge, nucleophile
A	ASP105	electrostatic stabiliser, hydrogen bond acceptor
A	THR11	electrostatic stabiliser, hydrogen bond donor
A	GLY12	electrostatic stabiliser, hydrogen bond donor
A	ASN13	electrostatic stabiliser, hydrogen bond donor
A	SER14	electrostatic stabiliser, hydrogen bond donor
A	CYS15	electrostatic stabiliser, hydrogen bond donor
A	ARG16	electrostatic stabiliser, hydrogen bond donor
A	SER17	electrostatic stabiliser, hydrogen bond donor
A	SER36

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