1LH0
Crystal Structure of Salmonella typhimurium OMP Synthase in Complex with MGPRPP and Orotate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| A | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| A | 0072528 | biological_process | pyrimidine-containing compound biosynthetic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| B | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| B | 0072528 | biological_process | pyrimidine-containing compound biosynthetic process |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VMLVDDVITAGtA |
| Chain | Residue | Details |
| A | VAL1120-ALA1132 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: in other chain => ECO:0000269|PubMed:7545004 |
| Chain | Residue | Details |
| A | SER1027 | |
| A | LYS1073 | |
| A | GLU1101 | |
| A | ASP1125 | |
| B | SER2027 | |
| B | LYS2073 | |
| B | GLU2101 | |
| B | ASP2125 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:7545004 |
| Chain | Residue | Details |
| A | PHE1035 | |
| B | GLY2106 | |
| B | ALA2129 | |
| B | GLN2157 | |
| A | LYS1100 | |
| A | ASP1104 | |
| A | GLY1106 | |
| A | ALA1129 | |
| A | GLN1157 | |
| B | PHE2035 | |
| B | LYS2100 | |
| B | ASP2104 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oro |
| Chain | Residue | Details |
| A | LYS1103 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1oro |
| Chain | Residue | Details |
| A | ASP1104 | |
| A | LYS1073 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oro |
| Chain | Residue | Details |
| B | LYS2073 |
