Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1LE6

CARBOXYLIC ESTER HYDROLASE, P 1 21 1 SPACE GROUP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001516	biological_process	prostaglandin biosynthetic process
A	0001669	cellular_component	acrosomal vesicle
A	0002532	biological_process	production of molecular mediator involved in inflammatory response
A	0003847	molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity
A	0004620	molecular_function	phospholipase activity
A	0004623	molecular_function	phospholipase A2 activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005764	cellular_component	lysosome
A	0006629	biological_process	lipid metabolic process
A	0006644	biological_process	phospholipid metabolic process
A	0006658	biological_process	phosphatidylserine metabolic process
A	0007411	biological_process	axon guidance
A	0009566	biological_process	fertilization
A	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
A	0010884	biological_process	positive regulation of lipid storage
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0019369	biological_process	arachidonic acid metabolic process
A	0031069	biological_process	hair follicle morphogenesis
A	0031410	cellular_component	cytoplasmic vesicle
A	0032308	biological_process	positive regulation of prostaglandin secretion
A	0034374	biological_process	low-density lipoprotein particle remodeling
A	0034638	biological_process	phosphatidylcholine catabolic process
A	0036335	biological_process	intestinal stem cell homeostasis
A	0042116	biological_process	macrophage activation
A	0042632	biological_process	cholesterol homeostasis
A	0043030	biological_process	regulation of macrophage activation
A	0043249	biological_process	erythrocyte maturation
A	0043433	biological_process	negative regulation of DNA-binding transcription factor activity
A	0046337	biological_process	phosphatidylethanolamine metabolic process
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046471	biological_process	phosphatidylglycerol metabolic process
A	0046473	biological_process	phosphatidic acid metabolic process
A	0046872	molecular_function	metal ion binding
A	0047498	molecular_function	calcium-dependent phospholipase A2 activity
A	0050482	biological_process	arachidonic acid secretion
A	0050728	biological_process	negative regulation of inflammatory response
A	0051247	biological_process	positive regulation of protein metabolic process
A	0051607	biological_process	defense response to virus
A	0051977	biological_process	lysophospholipid transport
A	0062234	biological_process	platelet activating factor catabolic process
A	0090238	biological_process	positive regulation of arachidonic acid secretion
A	0090370	biological_process	negative regulation of cholesterol efflux
A	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
A	1990830	biological_process	cellular response to leukemia inhibitory factor
A	2000344	biological_process	positive regulation of acrosome reaction
B	0001516	biological_process	prostaglandin biosynthetic process
B	0001669	cellular_component	acrosomal vesicle
B	0002532	biological_process	production of molecular mediator involved in inflammatory response
B	0003847	molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity
B	0004620	molecular_function	phospholipase activity
B	0004623	molecular_function	phospholipase A2 activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005543	molecular_function	phospholipid binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005764	cellular_component	lysosome
B	0006629	biological_process	lipid metabolic process
B	0006644	biological_process	phospholipid metabolic process
B	0006658	biological_process	phosphatidylserine metabolic process
B	0007411	biological_process	axon guidance
B	0009566	biological_process	fertilization
B	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
B	0010884	biological_process	positive regulation of lipid storage
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0019369	biological_process	arachidonic acid metabolic process
B	0031069	biological_process	hair follicle morphogenesis
B	0031410	cellular_component	cytoplasmic vesicle
B	0032308	biological_process	positive regulation of prostaglandin secretion
B	0034374	biological_process	low-density lipoprotein particle remodeling
B	0034638	biological_process	phosphatidylcholine catabolic process
B	0036335	biological_process	intestinal stem cell homeostasis
B	0042116	biological_process	macrophage activation
B	0042632	biological_process	cholesterol homeostasis
B	0043030	biological_process	regulation of macrophage activation
B	0043249	biological_process	erythrocyte maturation
B	0043433	biological_process	negative regulation of DNA-binding transcription factor activity
B	0046337	biological_process	phosphatidylethanolamine metabolic process
B	0046470	biological_process	phosphatidylcholine metabolic process
B	0046471	biological_process	phosphatidylglycerol metabolic process
B	0046473	biological_process	phosphatidic acid metabolic process
B	0046872	molecular_function	metal ion binding
B	0047498	molecular_function	calcium-dependent phospholipase A2 activity
B	0050482	biological_process	arachidonic acid secretion
B	0050728	biological_process	negative regulation of inflammatory response
B	0051247	biological_process	positive regulation of protein metabolic process
B	0051607	biological_process	defense response to virus
B	0051977	biological_process	lysophospholipid transport
B	0062234	biological_process	platelet activating factor catabolic process
B	0090238	biological_process	positive regulation of arachidonic acid secretion
B	0090370	biological_process	negative regulation of cholesterol efflux
B	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
B	1990830	biological_process	cellular response to leukemia inhibitory factor
B	2000344	biological_process	positive regulation of acrosome reaction
C	0001516	biological_process	prostaglandin biosynthetic process
C	0001669	cellular_component	acrosomal vesicle
C	0002532	biological_process	production of molecular mediator involved in inflammatory response
C	0003847	molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity
C	0004620	molecular_function	phospholipase activity
C	0004623	molecular_function	phospholipase A2 activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005543	molecular_function	phospholipid binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005764	cellular_component	lysosome
C	0006629	biological_process	lipid metabolic process
C	0006644	biological_process	phospholipid metabolic process
C	0006658	biological_process	phosphatidylserine metabolic process
C	0007411	biological_process	axon guidance
C	0009566	biological_process	fertilization
C	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
C	0010884	biological_process	positive regulation of lipid storage
C	0016042	biological_process	lipid catabolic process
C	0016787	molecular_function	hydrolase activity
C	0019369	biological_process	arachidonic acid metabolic process
C	0031069	biological_process	hair follicle morphogenesis
C	0031410	cellular_component	cytoplasmic vesicle
C	0032308	biological_process	positive regulation of prostaglandin secretion
C	0034374	biological_process	low-density lipoprotein particle remodeling
C	0034638	biological_process	phosphatidylcholine catabolic process
C	0036335	biological_process	intestinal stem cell homeostasis
C	0042116	biological_process	macrophage activation
C	0042632	biological_process	cholesterol homeostasis
C	0043030	biological_process	regulation of macrophage activation
C	0043249	biological_process	erythrocyte maturation
C	0043433	biological_process	negative regulation of DNA-binding transcription factor activity
C	0046337	biological_process	phosphatidylethanolamine metabolic process
C	0046470	biological_process	phosphatidylcholine metabolic process
C	0046471	biological_process	phosphatidylglycerol metabolic process
C	0046473	biological_process	phosphatidic acid metabolic process
C	0046872	molecular_function	metal ion binding
C	0047498	molecular_function	calcium-dependent phospholipase A2 activity
C	0050482	biological_process	arachidonic acid secretion
C	0050728	biological_process	negative regulation of inflammatory response
C	0051247	biological_process	positive regulation of protein metabolic process
C	0051607	biological_process	defense response to virus
C	0051977	biological_process	lysophospholipid transport
C	0062234	biological_process	platelet activating factor catabolic process
C	0090238	biological_process	positive regulation of arachidonic acid secretion
C	0090370	biological_process	negative regulation of cholesterol efflux
C	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
C	1990830	biological_process	cellular response to leukemia inhibitory factor
C	2000344	biological_process	positive regulation of acrosome reaction

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 461

Chain	Residue
A	PHE26
A	GLY28
A	GLY30
A	ASP47
A	HOH463
A	HOH469

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 462

Chain	Residue
B	ASP47
B	HOH467
B	HOH468
B	PHE26
B	GLY28
B	GLY30

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 463

Chain	Residue
C	PHE26
C	GLY28
C	GLY30
C	ASP47
C	HOH464
C	HOH489

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD B 464

Chain	Residue
B	ASP47
B	TYR50
B	THR51
B	GLU54
B	HOH468
B	HOH497
B	HOH611

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD B 465

Chain	Residue
A	ILE18
B	LYS22
B	GLN112
B	PHE113
B	HOH576
B	HOH620

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD B 466

Chain	Residue
B	TRP41
B	GLU93
B	CYS97
B	HOH515

Functional Information from PROSITE/UniProt

site_id	PS00118
Number of Residues	8
Details	PA2_HIS Phospholipase A2 histidine active site. CCHgHDcC

Chain	Residue	Details
A	CYS42-CYS49

site_id	PS00119
Number of Residues	11
Details	PA2_ASP Phospholipase A2 aspartic acid active site. LCKCDQEIaNC

Chain	Residue	Details
A	LEU87-CYS97

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000269\|PubMed:12161451

Chain	Residue	Details
A	ALA56
A	THR101
B	ALA56
B	THR101
C	ALA56
C	THR101

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:12161451, ECO:0007744\|PDB:1LE6, ECO:0007744\|PDB:1LE7

Chain	Residue	Details
A	ARG36
C	ALA38
C	ASP40
C	GLY57
A	ALA38
A	ASP40
A	GLY57
B	ARG36
B	ALA38
B	ASP40
B	GLY57
C	ARG36

site_id	SWS_FT_FI3
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN81
B	ASN81
C	ASN81

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1n29

Chain	Residue	Details
A	GLY28
A	HIS46
A	ASP91

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1n29

Chain	Residue	Details
B	GLY28
B	HIS46
B	ASP91

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1n29

Chain	Residue	Details
C	GLY28
C	HIS46
C	ASP91

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)