1LDJ
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000082 | biological_process | G1/S transition of mitotic cell cycle |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0006513 | biological_process | protein monoubiquitination |
| A | 0006915 | biological_process | apoptotic process |
| A | 0008283 | biological_process | cell population proliferation |
| A | 0009887 | biological_process | animal organ morphogenesis |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0019005 | cellular_component | SCF ubiquitin ligase complex |
| A | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| A | 0031146 | biological_process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| A | 0031461 | cellular_component | cullin-RING ubiquitin ligase complex |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| A | 0070936 | biological_process | protein K48-linked ubiquitination |
| A | 0097193 | biological_process | intrinsic apoptotic signaling pathway |
| A | 0160072 | molecular_function | ubiquitin ligase complex scaffold activity |
| A | 1990452 | cellular_component | Parkin-FBXW7-Cul1 ubiquitin ligase complex |
| B | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 201 |
| Chain | Residue |
| B | CYS42 |
| B | CYS45 |
| B | HIS80 |
| B | CYS83 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 202 |
| Chain | Residue |
| B | CYS75 |
| B | HIS77 |
| B | CYS94 |
| B | ASP97 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 203 |
| Chain | Residue |
| B | CYS56 |
| B | CYS68 |
| B | HIS82 |
| B | CYS53 |
Functional Information from PROSITE/UniProt
| site_id | PS01256 |
| Number of Residues | 28 |
| Details | CULLIN_1 Cullin family signature. IKkcIdiLIEKeYLeRvdgekdtYsYlA |
| Chain | Residue | Details |
| A | ILE749-ALA776 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 45 |
| Details | ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 |
| Chain | Residue | Details |
| B | CYS53-ASN98 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 11 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11961546, ECO:0007744|PDB:1LDJ, ECO:0007744|PDB:1LDK, ECO:0007744|PDB:1U6G, ECO:0007744|PDB:2HYE, ECO:0007744|PDB:3DPL, ECO:0007744|PDB:3DQV, ECO:0007744|PDB:3RTR, ECO:0007744|PDB:4F52, ECO:0007744|PDB:4P5O |
| Chain | Residue | Details |
| B | CYS42 | |
| B | CYS94 | |
| B | ASP97 | |
| B | CYS45 | |
| B | CYS53 | |
| B | CYS56 | |
| B | CYS68 | |
| B | CYS75 | |
| B | HIS77 | |
| B | HIS80 | |
| B | HIS82 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11961546, ECO:0007744|PDB:1LDJ, ECO:0007744|PDB:1LDK, ECO:0007744|PDB:1U6G, ECO:0007744|PDB:2HYE, ECO:0007744|PDB:3DQV, ECO:0007744|PDB:3RTR, ECO:0007744|PDB:4F52, ECO:0007744|PDB:4P5O |
| Chain | Residue | Details |
| B | CYS83 |
