1LBK
Crystal structure of a recombinant glutathione transferase, created by replacing the last seven residues of each subunit of the human class pi isoenzyme with the additional C-terminal helix of human class alpha isoenzyme
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SO4 B 505 |
| Chain | Residue |
| A | ASN66 |
| B | HOH506 |
| B | HOH507 |
| B | HOH553 |
| B | HOH633 |
| A | ARG70 |
| A | ASP94 |
| A | GLU97 |
| A | HOH530 |
| B | ASN66 |
| B | ARG70 |
| B | ASP94 |
| B | GLU97 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MES A 501 |
| Chain | Residue |
| A | TRP28 |
| A | GLU30 |
| A | PHE192 |
| A | GLU197 |
| A | HOH673 |
| B | HOH537 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MES B 502 |
| Chain | Residue |
| A | ASP171 |
| B | TRP28 |
| B | GLU30 |
| B | PHE192 |
| B | GLU197 |
| B | HOH510 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE GSH B 503 |
| Chain | Residue |
| A | ASP98 |
| B | TYR7 |
| B | PHE8 |
| B | ARG13 |
| B | TRP38 |
| B | LYS44 |
| B | GLY50 |
| B | GLN51 |
| B | LEU52 |
| B | PRO53 |
| B | GLN64 |
| B | SER65 |
| B | GLU205 |
| B | HOH513 |
| B | HOH520 |
| B | HOH551 |
| B | HOH619 |
| B | HOH643 |
| B | HOH682 |
| B | HOH727 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE GSH A 504 |
| Chain | Residue |
| A | TYR7 |
| A | PHE8 |
| A | ARG13 |
| A | TRP38 |
| A | LYS44 |
| A | GLN51 |
| A | LEU52 |
| A | PRO53 |
| A | GLN64 |
| A | SER65 |
| A | GLU205 |
| A | HOH516 |
| A | HOH523 |
| A | HOH525 |
| A | HOH538 |
| A | HOH604 |
| A | HOH620 |
| A | HOH665 |
| B | ASP98 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"1522586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19396894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19808963","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9012673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9245401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9351803","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9398518","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16421451","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19618965","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 158 |
| Details | Domain: {"description":"GST N-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 242 |
| Details | Domain: {"description":"GST C-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine; by EGFR","evidences":[{"source":"PubMed","id":"19254954","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P19157","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| A | TYR7 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| B | TYR7 |
