1LBF
CRYSTAL STRUCTURE OF INDOLE-3-GLYCEROL PHOSPHATE SYNTASE (IGPS)WITH REDUCED 1-(O-CABOXYPHENYLAMINO)-1-DEOXYRIBULOSE 5-PHOSPHATE (RCDRP)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | L-tryptophan biosynthetic process |
| A | 0004425 | molecular_function | indole-3-glycerol-phosphate synthase activity |
| A | 0006568 | biological_process | L-tryptophan metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE 137 A 300 |
| Chain | Residue |
| A | TRP8 |
| A | LEU184 |
| A | LEU187 |
| A | GLU210 |
| A | SER211 |
| A | GLY212 |
| A | LEU231 |
| A | GLY233 |
| A | SER234 |
| A | HOH901 |
| A | HOH902 |
| A | GLU51 |
| A | HOH1078 |
| A | HOH1171 |
| A | HOH1316 |
| A | HOH1318 |
| A | HOH1320 |
| A | LYS53 |
| A | SER56 |
| A | PRO57 |
| A | SER58 |
| A | PHE89 |
| A | LYS110 |
| A | ARG182 |
Functional Information from PROSITE/UniProt
| site_id | PS00614 |
| Number of Residues | 15 |
| Details | IGPS Indole-3-glycerol phosphate synthase signature. IIaEYKRKSPSgld....V |
| Chain | Residue | Details |
| A | ILE48-VAL62 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1pii |
| Chain | Residue | Details |
| A | GLU51 | |
| A | SER211 | |
| A | ASN180 | |
| A | LYS53 | |
| A | LYS110 | |
| A | GLU159 |
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 252 |
| Chain | Residue | Details |
| A | GLU51 | electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity, proton acceptor, proton donor |
| A | LYS53 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor |
| A | LYS110 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | GLU159 | activator, hydrogen bond acceptor, increase nucleophilicity |
| A | ASN180 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase acidity |
| A | GLU210 | electrostatic stabiliser |
| A | SER211 | electrostatic stabiliser, hydrogen bond donor |
