1LBA
THE STRUCTURE OF BACTERIOPHAGE T7 LYSOZYME, A ZINC AMIDASE AND AN INHIBITOR OF T7 RNA POLYMERASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001897 | biological_process | symbiont-mediated cytolysis of host cell |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008745 | molecular_function | N-acetylmuramoyl-L-alanine amidase activity |
| A | 0009253 | biological_process | peptidoglycan catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0032897 | biological_process | negative regulation of viral transcription |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0044659 | biological_process | viral release from host cell by cytolysis |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 151 |
| Chain | Residue |
| A | HIS17 |
| A | HIS122 |
| A | CYS130 |
| A | HOH199 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 122 |
| Details | Domain: {"description":"N-acetylmuramoyl-L-alanine amidase","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04111","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8171031","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LBA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Essential for amidase activity and zinc hydrate coordination","evidences":[{"source":"HAMAP-Rule","id":"MF_04111","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8171031","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for catalytic activity","evidences":[{"source":"PubMed","id":"8171031","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LBA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 8171031 |
| Chain | Residue | Details |
| A | LYS128 | |
| A | TYR46 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 586 |
| Chain | Residue | Details |
| A | HIS17 | |
| A | TYR46 | proton shuttle (general acid/base) |
| A | HIS122 | |
| A | LYS128 | electrostatic stabiliser |
| A | CYS130 |
