1LBA

THE STRUCTURE OF BACTERIOPHAGE T7 LYSOZYME, A ZINC AMIDASE AND AN INHIBITOR OF T7 RNA POLYMERASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0008152	biological_process	metabolic process
A	0008270	molecular_function	zinc ion binding
A	0008745	molecular_function	N-acetylmuramoyl-L-alanine amidase activity
A	0009253	biological_process	peptidoglycan catabolic process
A	0016787	molecular_function	hydrolase activity
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0032897	biological_process	negative regulation of viral transcription
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 151

Chain	Residue
A	HIS17
A	HIS122
A	CYS130
A	HOH199

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04111, ECO:0000269|PubMed:8171031, ECO:0007744|PDB:1LBA

Chain	Residue	Details
A	CYS18
A	HIS123
A	PRO131

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Essential for amidase activity and zinc hydrate coordination => ECO:0000255|HAMAP-Rule:MF_04111, ECO:0000269|PubMed:8171031

Chain	Residue	Details
A	HIS47

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Important for catalytic activity => ECO:0000269|PubMed:8171031, ECO:0007744|PDB:1LBA

Chain	Residue	Details
A	ALA129

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 586

Chain	Residue	Details
A	CYS18
A	HIS47	proton shuttle (general acid/base)
A	HIS123
A	ALA129	electrostatic stabiliser
A	PRO131

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