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1L8B

Cocrystal Structure of the Messenger RNA 5' Cap-binding Protein (eIF4E) bound to 7-methylGpppG

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003743molecular_functiontranslation initiation factor activity
A0005737cellular_componentcytoplasm
A0006413biological_processtranslational initiation
B0003723molecular_functionRNA binding
B0003743molecular_functiontranslation initiation factor activity
B0005737cellular_componentcytoplasm
B0006413biological_processtranslational initiation
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE MGP A 1000
ChainResidue
ATRP56
AHOH1044
AHOH1054
AHOH1070
AHOH1073
AHOH1096
BTHR205
AMET101
ATRP102
AGLU103
AARG157
ALYS162
ALYS206
AHOH1021
AHOH1029

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE MGP B 2000
ChainResidue
BTRP56
BMET101
BTRP102
BGLU103
BARG157
BLYS162
BHOH2013
BHOH2026
BHOH2039
BHOH2060
BHOH2070
BHOH2081
BHOH2085

Functional Information from PROSITE/UniProt
site_idPS00813
Number of Residues24
DetailsIF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW
ChainResidueDetails
AASP90-TRP113

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:10394359, ECO:0000269|PubMed:9200613
ChainResidueDetails
ATRP56
ATRP102
AARG157
ATHR205
BTRP56
BTRP102
BARG157
BTHR205

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKC and MKNK2 => ECO:0000269|PubMed:17689282
ChainResidueDetails
ASER209
BSER209

226707

PDB entries from 2024-10-30

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