1L1O

Structure of the human Replication Protein A (RPA) trimerization core

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000723	biological_process	telomere maintenance
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005662	cellular_component	DNA replication factor A complex
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006289	biological_process	nucleotide-excision repair
A	0006298	biological_process	mismatch repair
A	0006310	biological_process	DNA recombination
A	0006974	biological_process	DNA damage response
A	0035861	cellular_component	site of double-strand break
D	0000723	biological_process	telomere maintenance
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0003677	molecular_function	DNA binding
D	0003684	molecular_function	damaged DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005662	cellular_component	DNA replication factor A complex
D	0006260	biological_process	DNA replication
D	0006281	biological_process	DNA repair
D	0006284	biological_process	base-excision repair
D	0006289	biological_process	nucleotide-excision repair
D	0006298	biological_process	mismatch repair
D	0006310	biological_process	DNA recombination
D	0006974	biological_process	DNA damage response
D	0035861	cellular_component	site of double-strand break

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 1

Chain	Residue
C	CYS481
C	THR483
C	CYS486
C	CYS500
C	CYS503

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 2

Chain	Residue
F	CYS481
F	CYS486
F	CYS500
F	CYS503

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"26474068","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"20705237","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---