1L1O

Structure of the human Replication Protein A (RPA) trimerization core

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000723	biological_process	telomere maintenance
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005662	cellular_component	DNA replication factor A complex
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006289	biological_process	nucleotide-excision repair
A	0006298	biological_process	mismatch repair
A	0006310	biological_process	DNA recombination
A	0007346	biological_process	regulation of mitotic cell cycle
A	0031981	cellular_component	nuclear lumen
A	0035861	cellular_component	site of double-strand break
A	0042127	biological_process	regulation of cell population proliferation
C	0003677	molecular_function	DNA binding
C	0005634	cellular_component	nucleus
C	0006260	biological_process	DNA replication
C	0006281	biological_process	DNA repair
C	0006310	biological_process	DNA recombination
D	0000723	biological_process	telomere maintenance
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0003677	molecular_function	DNA binding
D	0003684	molecular_function	damaged DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005662	cellular_component	DNA replication factor A complex
D	0006260	biological_process	DNA replication
D	0006281	biological_process	DNA repair
D	0006284	biological_process	base-excision repair
D	0006289	biological_process	nucleotide-excision repair
D	0006298	biological_process	mismatch repair
D	0006310	biological_process	DNA recombination
D	0007346	biological_process	regulation of mitotic cell cycle
D	0031981	cellular_component	nuclear lumen
D	0035861	cellular_component	site of double-strand break
D	0042127	biological_process	regulation of cell population proliferation
F	0003677	molecular_function	DNA binding
F	0005634	cellular_component	nucleus
F	0006260	biological_process	DNA replication
F	0006281	biological_process	DNA repair
F	0006310	biological_process	DNA recombination

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 1

Chain	Residue
C	CYS481
C	THR483
C	CYS486
C	CYS500
C	CYS503

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 2

Chain	Residue
F	CYS481
F	CYS486
F	CYS500
F	CYS503

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	ZN_FING: C4-type => ECO:0000255

Chain	Residue	Details
C	CYS481-CYS503
F	CYS481-CYS503

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site_id	SWS_FT_FI2
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:20705237

Chain	Residue	Details
C	LYS449
C	LYS577
F	LYS449
D	LYS23
F	LYS577
D	LYS39
D	LYS88

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26474068

Chain	Residue	Details
C	LYS458
C	LYS553
F	LYS458
F	LYS553

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