1L1E
Crystal Structure of Mycolic Acid Cyclopropane Synthase PcaA Complexed with S-adenosyl-L-homocysteine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008610 | biological_process | lipid biosynthetic process |
| A | 0008825 | molecular_function | cyclopropane-fatty-acyl-phospholipid synthase activity |
| A | 0032259 | biological_process | methylation |
| A | 0042783 | biological_process | evasion of host immune response |
| A | 0046500 | biological_process | S-adenosylmethionine metabolic process |
| A | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
| A | 0071768 | biological_process | mycolic acid biosynthetic process |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008610 | biological_process | lipid biosynthetic process |
| B | 0008825 | molecular_function | cyclopropane-fatty-acyl-phospholipid synthase activity |
| B | 0032259 | biological_process | methylation |
| B | 0042783 | biological_process | evasion of host immune response |
| B | 0046500 | biological_process | S-adenosylmethionine metabolic process |
| B | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
| B | 0071768 | biological_process | mycolic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CO3 A 903 |
| Chain | Residue |
| A | SER34 |
| A | CYS35 |
| A | GLY137 |
| A | GLU140 |
| A | HIS167 |
| A | ILE169 |
| A | TYR232 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CO3 B 904 |
| Chain | Residue |
| B | GLY137 |
| B | GLU140 |
| B | HIS167 |
| B | THR168 |
| B | ILE169 |
| B | SER34 |
| B | CYS35 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SAH A 900 |
| Chain | Residue |
| A | THR32 |
| A | TYR33 |
| A | SER34 |
| A | GLY72 |
| A | GLY74 |
| A | THR94 |
| A | LEU95 |
| A | GLN99 |
| A | GLY122 |
| A | TRP123 |
| A | GLU124 |
| A | ILE136 |
| A | GLY137 |
| A | ALA138 |
| A | ARG146 |
| A | HOH907 |
| A | HOH909 |
| A | HOH973 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SAH B 901 |
| Chain | Residue |
| B | THR32 |
| B | TYR33 |
| B | SER34 |
| B | GLY72 |
| B | GLY74 |
| B | THR94 |
| B | LEU95 |
| B | GLN99 |
| B | GLY122 |
| B | TRP123 |
| B | ILE136 |
| B | GLY137 |
| B | ALA138 |
| B | PHE142 |
| B | HOH905 |
| B | HOH906 |
| B | HOH908 |
| B | HOH911 |
| B | HOH919 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS269 | |
| B | CYS269 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | TYR33 | |
| A | LEU68 | |
| A | THR94 | |
| A | TRP123 | |
| B | TYR33 | |
| B | LEU68 | |
| B | THR94 | |
| B | TRP123 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0007744|PubMed:21969609 |
| Chain | Residue | Details |
| A | SER2 | |
| B | SER2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:22621931 |
| Chain | Residue | Details |
| A | THR168 | |
| A | THR183 | |
| B | THR168 | |
| B | THR183 |
