1L0N

native structure of bovine mitochondrial cytochrome bc1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0016020	cellular_component	membrane
A	0032991	cellular_component	protein-containing complex
A	0046872	molecular_function	metal ion binding
B	0004222	molecular_function	metalloendopeptidase activity
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006508	biological_process	proteolysis
B	0016020	cellular_component	membrane
B	0045275	cellular_component	respiratory chain complex III
B	0046872	molecular_function	metal ion binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0022904	biological_process	respiratory electron transport chain
C	0031966	cellular_component	mitochondrial membrane
C	0045275	cellular_component	respiratory chain complex III
C	0046872	molecular_function	metal ion binding
C	0048039	molecular_function	ubiquinone binding
C	1902600	biological_process	proton transmembrane transport
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
E	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0016020	cellular_component	membrane
F	0045275	cellular_component	respiratory chain complex III
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0016020	cellular_component	membrane
G	0021539	biological_process	subthalamus development
G	0021548	biological_process	pons development
G	0021680	biological_process	cerebellar Purkinje cell layer development
G	0021766	biological_process	hippocampus development
G	0021794	biological_process	thalamus development
G	0021854	biological_process	hypothalamus development
G	0021860	biological_process	pyramidal neuron development
G	0030901	biological_process	midbrain development
G	0045275	cellular_component	respiratory chain complex III
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
I	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0016020	cellular_component	membrane
J	0045275	cellular_component	respiratory chain complex III
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
K	0016020	cellular_component	membrane
K	0045275	cellular_component	respiratory chain complex III

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEM C 381

Chain	Residue
C	TRP31
C	TRP113
C	GLY116
C	VAL117
C	LEU119
C	HIS196
C	LEU197
C	LEU200
C	SER205
C	ASN206
C	GLY34
C	LEU37
C	HIS97
C	VAL98
C	ARG100
C	SER106
C	PHE109
C	THR112

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEM C 382

Chain	Residue
C	GLN44
C	GLY48
C	LEU51
C	ARG80
C	HIS83
C	ALA84
C	ALA87
C	THR126
C	GLY130
C	LEU133
C	PRO134
C	PHE179
C	HIS182
C	PHE183
C	PRO186
C	PHE187
C	TYR273

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM D 242

Chain	Residue
D	VAL36
D	CYS37
D	CYS40
D	HIS41
D	ASN105
D	PRO110
D	ARG120
D	TYR126
D	LEU131
D	PHE153
D	ALA157
D	ILE158
D	GLY159
D	MET160
D	VAL186

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FES E 197

Chain	Residue
E	CYS139
E	HIS141
E	LEU142
E	CYS144
E	CYS158
E	PRO159
E	CYS160
E	HIS161
E	GLY162

---

Functional Information from PROSITE/UniProt

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsryensnnlGtSHLLRLAsSlTT

Chain	Residue	Details
B	GLY54-THR77

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:9651245

Chain	Residue	Details
K	MET1-GLN12
D	GLU124
C	TRP113-LEU133
C	PHE178-LEU198
C	ILE226-ALA246
C	LEU288-HIS308
C	LEU320-GLY340
C	TYR347-PRO367

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	TRANSMEM: Helical => ECO:0000269|PubMed:9651245

Chain	Residue	Details
K	LEU13-ALA35
F	TYR83
F	GLU96

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:9651245

Chain	Residue	Details
K	THR36-ASP56
F	SER88

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:9651245, ECO:0007744|PDB:1BE3, ECO:0007744|PDB:1BGY

Chain	Residue	Details
E	CYS139
E	HIS141
E	CYS158
E	HIS161
E	SER163

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15312779, ECO:0000269|PubMed:16024040, ECO:0007744|PDB:1PP9, ECO:0007744|PDB:1SQV, ECO:0007744|PDB:2A06, ECO:0007744|PDB:2YBB

Chain	Residue	Details
C	HIS201

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ndo

Chain	Residue	Details
E	HIS161

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ndo

Chain	Residue	Details
A	GLU60

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site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ndo

Chain	Residue	Details
B	ARG70

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