1KZL
Riboflavin Synthase from S.pombe bound to Carboxyethyllumazine
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HG A 1001 |
| Chain | Residue |
| A | CYS48 |
| A | GLN100 |
| A | CRM502 |
| A | HOH1019 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE CRM A 501 |
| Chain | Residue |
| A | SER146 |
| A | LEU147 |
| A | THR148 |
| A | MET160 |
| A | MET161 |
| A | ILE162 |
| A | TYR164 |
| A | THR165 |
| A | HOH1053 |
| A | HOH1084 |
| A | HOH1098 |
| A | GLY4 |
| A | LEU5 |
| A | VAL6 |
| A | TYR139 |
| A | THR145 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE CRM A 502 |
| Chain | Residue |
| A | THR47 |
| A | CYS48 |
| A | LEU49 |
| A | THR50 |
| A | GLY62 |
| A | ILE63 |
| A | ALA64 |
| A | SER67 |
| A | GLY101 |
| A | HIS102 |
| A | VAL103 |
| A | LYS137 |
| A | HG1001 |
| A | HOH1004 |
| A | HOH1019 |
| A | HOH1086 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 96 |
| Details | Repeat: {"description":"Lumazine-binding 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 97 |
| Details | Repeat: {"description":"Lumazine-binding 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12377123","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"UniProtKB","id":"Q2YN92","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | a catalytic site defined by CSA, PubMed 12877878, 18298940 |
| Chain | Residue | Details |
| A | HIS102 | |
| A | THR148 | |
| A | CYS48 | |
| A | SER41 | |
| A | THR50 |
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 247 |
| Chain | Residue | Details |
| A | PHE2 | electrostatic stabiliser, enhance reactivity, increase acidity, increase nucleophilicity |
| A | SER41 | electrostatic stabiliser, hydrogen bond donor, increase acidity, increase basicity, increase nucleophilicity |
| A | CYS48 | activator, covalently attached, hydrogen bond acceptor, hydrogen bond donor, increase electrophilicity, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | THR50 | electrostatic stabiliser, hydrogen bond donor, increase acidity, increase basicity |
| A | ALA64 | electrostatic stabiliser, hydrogen bond donor |
| A | HIS102 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | THR148 | electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity |
