1KYQ
Met8p: A bifunctional NAD-dependent dehydrogenase and ferrochelatase involved in siroheme synthesis.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000103 | biological_process | sulfate assimilation |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004325 | molecular_function | ferrochelatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005575 | cellular_component | cellular_component |
| A | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019354 | biological_process | siroheme biosynthetic process |
| A | 0043115 | molecular_function | precorrin-2 dehydrogenase activity |
| A | 0051266 | molecular_function | sirohydrochlorin ferrochelatase activity |
| B | 0000103 | biological_process | sulfate assimilation |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004325 | molecular_function | ferrochelatase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005575 | cellular_component | cellular_component |
| B | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019354 | biological_process | siroheme biosynthetic process |
| B | 0043115 | molecular_function | precorrin-2 dehydrogenase activity |
| B | 0051266 | molecular_function | sirohydrochlorin ferrochelatase activity |
| C | 0000103 | biological_process | sulfate assimilation |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004325 | molecular_function | ferrochelatase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005575 | cellular_component | cellular_component |
| C | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019354 | biological_process | siroheme biosynthetic process |
| C | 0043115 | molecular_function | precorrin-2 dehydrogenase activity |
| C | 0051266 | molecular_function | sirohydrochlorin ferrochelatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE NAD A 800 |
| Chain | Residue |
| A | GLY20 |
| A | ASP92 |
| A | PHE93 |
| A | ILE114 |
| A | PRO115 |
| A | HOH811 |
| A | HOH839 |
| A | HOH904 |
| A | HOH915 |
| A | GLY21 |
| A | GLY22 |
| A | GLU23 |
| A | VAL24 |
| A | VAL42 |
| A | SER43 |
| A | PRO44 |
| A | ASP45 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAD B 801 |
| Chain | Residue |
| B | ILE19 |
| B | GLY20 |
| B | GLY21 |
| B | GLY22 |
| B | GLU23 |
| B | VAL24 |
| B | VAL42 |
| B | SER43 |
| B | PRO44 |
| B | ASP45 |
| B | ASP92 |
| B | PHE93 |
| B | CYS113 |
| B | ILE114 |
| B | PRO115 |
| B | ALA140 |
| B | ASP141 |
| B | HOH803 |
| B | HOH808 |
| B | HOH809 |
| B | HOH822 |
| B | HOH847 |
| B | HOH883 |
| B | HOH968 |
| B | HOH986 |
| B | HOH991 |
| B | HOH1017 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NAD C 802 |
| Chain | Residue |
| C | ILE19 |
| C | GLY20 |
| C | GLY21 |
| C | GLY22 |
| C | GLU23 |
| C | VAL24 |
| C | VAL42 |
| C | SER43 |
| C | PRO44 |
| C | ASP45 |
| C | ASP92 |
| C | PHE93 |
| C | CYS113 |
| C | ILE114 |
| C | ALA140 |
| C | ASP141 |
| C | HOH809 |
| C | HOH811 |
| C | HOH812 |
| C | HOH877 |
| C | HOH925 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11980703","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11980703, 12196147 |
| Chain | Residue | Details |
| A | ASP141 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11980703, 12196147 |
| Chain | Residue | Details |
| B | ASP141 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11980703, 12196147 |
| Chain | Residue | Details |
| C | ASP141 |
| site_id | MCSA1 |
| Number of Residues | 1 |
| Details | M-CSA 610 |
| Chain | Residue | Details |
| A | ASN153 | proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 1 |
| Details | M-CSA 610 |
| Chain | Residue | Details |
| B | ASN153 | proton acceptor, proton donor |
| site_id | MCSA3 |
| Number of Residues | 1 |
| Details | M-CSA 610 |
| Chain | Residue | Details |
| C | ASN153 | proton acceptor, proton donor |
