1KWP
Crystal Structure of MAPKAP2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002224 | biological_process | toll-like receptor signaling pathway |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004683 | molecular_function | calcium/calmodulin-dependent protein kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005516 | molecular_function | calmodulin binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006691 | biological_process | leukotriene metabolic process |
| A | 0006954 | biological_process | inflammatory response |
| A | 0006974 | biological_process | DNA damage response |
| A | 0009931 | molecular_function | calcium-dependent protein serine/threonine kinase activity |
| A | 0010803 | biological_process | regulation of tumor necrosis factor-mediated signaling pathway |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032496 | biological_process | response to lipopolysaccharide |
| A | 0032675 | biological_process | regulation of interleukin-6 production |
| A | 0032680 | biological_process | regulation of tumor necrosis factor production |
| A | 0034097 | biological_process | response to cytokine |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0035924 | biological_process | cellular response to vascular endothelial growth factor stimulus |
| A | 0043488 | biological_process | regulation of mRNA stability |
| A | 0044351 | biological_process | macropinocytosis |
| A | 0048010 | biological_process | vascular endothelial growth factor receptor signaling pathway |
| A | 0051019 | molecular_function | mitogen-activated protein kinase binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070935 | biological_process | 3'-UTR-mediated mRNA stabilization |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 1900034 | biological_process | regulation of cellular response to heat |
| B | 0000165 | biological_process | MAPK cascade |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0002224 | biological_process | toll-like receptor signaling pathway |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0004683 | molecular_function | calcium/calmodulin-dependent protein kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005516 | molecular_function | calmodulin binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0006691 | biological_process | leukotriene metabolic process |
| B | 0006954 | biological_process | inflammatory response |
| B | 0006974 | biological_process | DNA damage response |
| B | 0009931 | molecular_function | calcium-dependent protein serine/threonine kinase activity |
| B | 0010803 | biological_process | regulation of tumor necrosis factor-mediated signaling pathway |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032496 | biological_process | response to lipopolysaccharide |
| B | 0032675 | biological_process | regulation of interleukin-6 production |
| B | 0032680 | biological_process | regulation of tumor necrosis factor production |
| B | 0034097 | biological_process | response to cytokine |
| B | 0035556 | biological_process | intracellular signal transduction |
| B | 0035924 | biological_process | cellular response to vascular endothelial growth factor stimulus |
| B | 0043488 | biological_process | regulation of mRNA stability |
| B | 0044351 | biological_process | macropinocytosis |
| B | 0048010 | biological_process | vascular endothelial growth factor receptor signaling pathway |
| B | 0051019 | molecular_function | mitogen-activated protein kinase binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070935 | biological_process | 3'-UTR-mediated mRNA stabilization |
| B | 0106310 | molecular_function | protein serine kinase activity |
| B | 1900034 | biological_process | regulation of cellular response to heat |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG A 401 |
| Chain | Residue |
| A | GLN96 |
| A | CYS98 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG A 402 |
| Chain | Residue |
| A | CYS114 |
| A | PRO115 |
| A | TYR176 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HG A 403 |
| Chain | Residue |
| A | HIS116 |
| A | SER169 |
| A | LEU203 |
| A | HOH465 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG A 404 |
| Chain | Residue |
| A | LEU95 |
| A | CYS133 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG A 405 |
| Chain | Residue |
| A | CYS140 |
| A | HOH458 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG A 406 |
| Chain | Residue |
| A | TYR240 |
| A | CYS244 |
| A | MET363 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG A 407 |
| Chain | Residue |
| A | TYR254 |
| A | CYS258 |
| A | PRO287 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE HG B 401 |
| Chain | Residue |
| B | CYS98 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG B 402 |
| Chain | Residue |
| B | CYS114 |
| B | TYR176 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HG B 403 |
| Chain | Residue |
| B | HIS116 |
| B | SER169 |
| B | ILE170 |
| B | LEU203 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG B 404 |
| Chain | Residue |
| B | LEU95 |
| B | CYS133 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG B 405 |
| Chain | Residue |
| B | ALA91 |
| B | CYS140 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG B 406 |
| Chain | Residue |
| B | TYR240 |
| B | CYS244 |
| B | MET363 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HG B 407 |
| Chain | Residue |
| B | TYR254 |
| B | LEU257 |
| B | CYS258 |
| B | TRP291 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGLGINGKVLqIfnkrtqek..........FALK |
| Chain | Residue | Details |
| A | LEU70-LYS93 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDVKpeNLLY |
| Chain | Residue | Details |
| A | ILE182-TYR194 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 72 |
| Details | Region: {"description":"Autoinhibitory helix","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Motif: {"description":"Nuclear export signal (NES)"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Motif: {"description":"Bipartite nuclear localization signal 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by MAPK14","evidences":[{"source":"PubMed","id":"8846784","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by MAPK14","evidences":[{"source":"PubMed","id":"8846784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"21131586","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP186 | |
| A | GLU190 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP186 | |
| B | GLU190 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP186 | |
| A | LYS188 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP186 | |
| B | LYS188 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP186 | |
| A | ASN191 | |
| A | LYS188 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP186 | |
| B | ASN191 | |
| B | LYS188 |
