Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1KWP

Crystal Structure of MAPKAP2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0000166	molecular_function	nucleotide binding
A	0002224	biological_process	toll-like receptor signaling pathway
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004683	molecular_function	calcium/calmodulin-dependent protein kinase activity
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006468	biological_process	protein phosphorylation
A	0006691	biological_process	leukotriene metabolic process
A	0006954	biological_process	inflammatory response
A	0006974	biological_process	DNA damage response
A	0009931	molecular_function	calcium-dependent protein serine/threonine kinase activity
A	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0032496	biological_process	response to lipopolysaccharide
A	0032675	biological_process	regulation of interleukin-6 production
A	0032680	biological_process	regulation of tumor necrosis factor production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0034097	biological_process	response to cytokine
A	0035556	biological_process	intracellular signal transduction
A	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
A	0036064	cellular_component	ciliary basal body
A	0038066	biological_process	p38MAPK cascade
A	0043488	biological_process	regulation of mRNA stability
A	0044351	biological_process	macropinocytosis
A	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
A	0048255	biological_process	mRNA stabilization
A	0048839	biological_process	inner ear development
A	0051019	molecular_function	mitogen-activated protein kinase binding
A	0060907	biological_process	positive regulation of macrophage cytokine production
A	0070062	cellular_component	extracellular exosome
A	0070935	biological_process	3'-UTR-mediated mRNA stabilization
A	0106310	molecular_function	protein serine kinase activity
A	1900034	biological_process	regulation of cellular response to heat
B	0000165	biological_process	MAPK cascade
B	0000166	molecular_function	nucleotide binding
B	0002224	biological_process	toll-like receptor signaling pathway
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004683	molecular_function	calcium/calmodulin-dependent protein kinase activity
B	0005515	molecular_function	protein binding
B	0005516	molecular_function	calmodulin binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0006468	biological_process	protein phosphorylation
B	0006691	biological_process	leukotriene metabolic process
B	0006954	biological_process	inflammatory response
B	0006974	biological_process	DNA damage response
B	0009931	molecular_function	calcium-dependent protein serine/threonine kinase activity
B	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0032496	biological_process	response to lipopolysaccharide
B	0032675	biological_process	regulation of interleukin-6 production
B	0032680	biological_process	regulation of tumor necrosis factor production
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0034097	biological_process	response to cytokine
B	0035556	biological_process	intracellular signal transduction
B	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
B	0036064	cellular_component	ciliary basal body
B	0038066	biological_process	p38MAPK cascade
B	0043488	biological_process	regulation of mRNA stability
B	0044351	biological_process	macropinocytosis
B	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
B	0048255	biological_process	mRNA stabilization
B	0048839	biological_process	inner ear development
B	0051019	molecular_function	mitogen-activated protein kinase binding
B	0060907	biological_process	positive regulation of macrophage cytokine production
B	0070062	cellular_component	extracellular exosome
B	0070935	biological_process	3'-UTR-mediated mRNA stabilization
B	0106310	molecular_function	protein serine kinase activity
B	1900034	biological_process	regulation of cellular response to heat

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HG A 401

Chain	Residue
A	GLN96
A	CYS98

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG A 402

Chain	Residue
A	CYS114
A	PRO115
A	TYR176

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HG A 403

Chain	Residue
A	HIS116
A	SER169
A	LEU203
A	HOH465

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HG A 404

Chain	Residue
A	LEU95
A	CYS133

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HG A 405

Chain	Residue
A	CYS140
A	HOH458

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG A 406

Chain	Residue
A	TYR240
A	CYS244
A	MET363

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG A 407

Chain	Residue
A	TYR254
A	CYS258
A	PRO287

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HG B 401

Chain	Residue
B	CYS98

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HG B 402

Chain	Residue
B	CYS114
B	TYR176

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HG B 403

Chain	Residue
B	HIS116
B	SER169
B	ILE170
B	LEU203

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HG B 404

Chain	Residue
B	LEU95
B	CYS133

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HG B 405

Chain	Residue
B	ALA91
B	CYS140

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG B 406

Chain	Residue
B	TYR240
B	CYS244
B	MET363

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HG B 407

Chain	Residue
B	TYR254
B	LEU257
B	CYS258
B	TRP291

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGLGINGKVLqIfnkrtqek..........FALK

Chain	Residue	Details
A	LEU70-LYS93

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDVKpeNLLY

Chain	Residue	Details
A	ILE182-TYR194

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Region: {"description":"Autoinhibitory helix","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	18
Details	Motif: {"description":"Nuclear export signal (NES)"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Motif: {"description":"Bipartite nuclear localization signal 1"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by MAPK14","evidences":[{"source":"PubMed","id":"8846784","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by MAPK14","evidences":[{"source":"PubMed","id":"8846784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"21131586","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP186
A	GLU190

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP186
B	GLU190

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP186
A	LYS188

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP186
B	LYS188

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP186
A	ASN191
A	LYS188

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP186
B	ASN191
B	LYS188

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)