1KUG

Crystal Structure of a Taiwan Habu Venom Metalloproteinase complexed with its endogenous inhibitor pENW

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CD A 981

Chain	Residue
A	HIS144
A	HIS148
A	HIS154
B	TRP253
B	HOH413

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CD A 982

Chain	Residue
A	HOH349
A	HIS36
A	ASP156
A	ASP158
A	HOH348

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CD A 983

Chain	Residue
A	ASP181
A	ASP185
A	HOH325
A	HOH431
A	HOH433

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 984

Chain	Residue
A	HIS18
A	HOH583
A	HOH721
A	HOH821

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 985

Chain	Residue
A	GLN7
A	ASN50
A	HOH319
A	HOH320
A	HOH438
A	HOH666

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 986

Chain	Residue
A	ASP194
A	HOH442
A	HOH571

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 987

Chain	Residue
A	PRO203
A	HOH392
A	HOH598
A	HOH746
A	HOH747
A	HOH837

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CD A 988

Chain	Residue
A	HIS131
A	HOH354
A	HOH355
A	HOH356
A	HOH424

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 989

Chain	Residue
A	HOH380
A	HOH386
A	HOH550
A	HOH551
A	HOH552
A	HOH836

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 990

Chain	Residue
A	GLU85
A	GLU85
A	HOH617
A	HOH617
A	HOH618
A	HOH618

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 991

Chain	Residue
A	GLU85
A	GLU85
A	GLU121
A	HOH455
A	HOH803
A	HOH803

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TMTHELGHNL

Chain	Residue	Details
A	THR141-LEU150

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	195
Details	Domain: {"description":"Peptidase M12B","evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12071970","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KUG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KUK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12071970","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12077431","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KUF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KUG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KUI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KUK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---