1KU6

Fasciculin 2-Mouse Acetylcholinesterase Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001919	biological_process	regulation of receptor recycling
A	0002076	biological_process	osteoblast development
A	0003990	molecular_function	acetylcholinesterase activity
A	0004104	molecular_function	cholinesterase activity
A	0005515	molecular_function	protein binding
A	0005518	molecular_function	collagen binding
A	0005576	cellular_component	extracellular region
A	0005604	cellular_component	basement membrane
A	0005615	cellular_component	extracellular space
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0006581	biological_process	acetylcholine catabolic process
A	0007155	biological_process	cell adhesion
A	0009986	cellular_component	cell surface
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0017171	molecular_function	serine hydrolase activity
A	0031594	cellular_component	neuromuscular junction
A	0031623	biological_process	receptor internalization
A	0042166	molecular_function	acetylcholine binding
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043236	molecular_function	laminin binding
A	0045202	cellular_component	synapse
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	0060041	biological_process	retina development in camera-type eye
A	0095500	biological_process	acetylcholine receptor signaling pathway
A	0098552	cellular_component	side of membrane
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	0005576	cellular_component	extracellular region
B	0035821	biological_process	modulation of process of another organism
B	0090729	molecular_function	toxin activity

Functional Information from PROSITE/UniProt

site_id	PS00122
Number of Residues	16
Details	CARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGdpmsVtLfGeSAG

Chain	Residue	Details
A	PHE190-GLY205

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site_id	PS00272
Number of Residues	19
Details	SNAKE_TOXIN Snake toxins signature. GCg..CPpgddnlevk.CCtsP

Chain	Residue	Details
B	GLY38-PRO56

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site_id	PS00941
Number of Residues	11
Details	CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNVWtP

Chain	Residue	Details
A	GLU94-PRO104

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Blocks the entrance of the active site gorge of hAChE => ECO:0000303|PubMed:23679855

Chain	Residue	Details
B	MET33

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
A	GLU334
A	HIS447

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN265

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine

Chain	Residue	Details
A	ASN350
A	ASN464

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1qe3

Chain	Residue	Details
A	GLU334
A	HIS447
A	SER203

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