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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1KPK

Crystal Structure of the ClC Chloride Channel from E. coli

Functional Information from GO Data
ChainGOidnamespacecontents
A0005247molecular_functionvoltage-gated chloride channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006821biological_processchloride transport
A0015108molecular_functionchloride transmembrane transporter activity
A0015297molecular_functionantiporter activity
A0016020cellular_componentmembrane
A0042802molecular_functionidentical protein binding
A0055085biological_processtransmembrane transport
A0062158molecular_functionchloride:proton antiporter activity
A1902476biological_processchloride transmembrane transport
A1902600biological_processproton transmembrane transport
A1990451biological_processcellular stress response to acidic pH
B0005247molecular_functionvoltage-gated chloride channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006821biological_processchloride transport
B0015108molecular_functionchloride transmembrane transporter activity
B0015297molecular_functionantiporter activity
B0016020cellular_componentmembrane
B0042802molecular_functionidentical protein binding
B0055085biological_processtransmembrane transport
B0062158molecular_functionchloride:proton antiporter activity
B1902476biological_processchloride transmembrane transport
B1902600biological_processproton transmembrane transport
B1990451biological_processcellular stress response to acidic pH
C0005247molecular_functionvoltage-gated chloride channel activity
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006821biological_processchloride transport
C0015108molecular_functionchloride transmembrane transporter activity
C0015297molecular_functionantiporter activity
C0016020cellular_componentmembrane
C0042802molecular_functionidentical protein binding
C0055085biological_processtransmembrane transport
C0062158molecular_functionchloride:proton antiporter activity
C1902476biological_processchloride transmembrane transport
C1902600biological_processproton transmembrane transport
C1990451biological_processcellular stress response to acidic pH
D0005247molecular_functionvoltage-gated chloride channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006821biological_processchloride transport
D0015108molecular_functionchloride transmembrane transporter activity
D0015297molecular_functionantiporter activity
D0016020cellular_componentmembrane
D0042802molecular_functionidentical protein binding
D0055085biological_processtransmembrane transport
D0062158molecular_functionchloride:proton antiporter activity
D1902476biological_processchloride transmembrane transport
D1902600biological_processproton transmembrane transport
D1990451biological_processcellular stress response to acidic pH
E0005247molecular_functionvoltage-gated chloride channel activity
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006821biological_processchloride transport
E0015108molecular_functionchloride transmembrane transporter activity
E0015297molecular_functionantiporter activity
E0016020cellular_componentmembrane
E0042802molecular_functionidentical protein binding
E0055085biological_processtransmembrane transport
E0062158molecular_functionchloride:proton antiporter activity
E1902476biological_processchloride transmembrane transport
E1902600biological_processproton transmembrane transport
E1990451biological_processcellular stress response to acidic pH
F0005247molecular_functionvoltage-gated chloride channel activity
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0006821biological_processchloride transport
F0015108molecular_functionchloride transmembrane transporter activity
F0015297molecular_functionantiporter activity
F0016020cellular_componentmembrane
F0042802molecular_functionidentical protein binding
F0055085biological_processtransmembrane transport
F0062158molecular_functionchloride:proton antiporter activity
F1902476biological_processchloride transmembrane transport
F1902600biological_processproton transmembrane transport
F1990451biological_processcellular stress response to acidic pH
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1296
DetailsTransmembrane: {"description":"Helical"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues318
DetailsTopological domain: {"description":"Periplasmic"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues312
DetailsIntramembrane: {"description":"Helical"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues192
DetailsTopological domain: {"description":"Cytoplasmic"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues36
DetailsIntramembrane: {"description":"Note=Loop between two helices"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues24
DetailsMotif: {"description":"Selectivity filter part_1"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues24
DetailsMotif: {"description":"Selectivity filter part_2"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues24
DetailsMotif: {"description":"Selectivity filter part_3"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12649487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16341087","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18678918","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1OTT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OTU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12649487","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OTS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ENE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6LSC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12649487","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OTT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12649487","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OTS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OTT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ENE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6LSC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues6
DetailsSite: {"description":"Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues6
DetailsSite: {"description":"Mediates proton transfer from the protein to the inner aqueous phase"}
ChainResidueDetails

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PDB entries from 2025-12-17

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