1KPI
Crystal Structure of mycolic acid cyclopropane synthase CmaA2 complexed with SAH and DDDMAB
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001666 | biological_process | response to hypoxia |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008610 | biological_process | lipid biosynthetic process |
| A | 0008825 | molecular_function | cyclopropane-fatty-acyl-phospholipid synthase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0046500 | biological_process | S-adenosylmethionine metabolic process |
| A | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
| A | 0071766 | biological_process | Actinobacterium-type cell wall biogenesis |
| A | 0071768 | biological_process | mycolic acid biosynthetic process |
| A | 0071769 | biological_process | mycolate cell wall layer assembly |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CO3 A 902 |
| Chain | Residue |
| A | SER42 |
| A | CYS43 |
| A | GLY145 |
| A | GLU148 |
| A | HIS182 |
| A | THR183 |
| A | ILE184 |
| A | TYR247 |
| A | 10A901 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 903 |
| Chain | Residue |
| A | ASN28 |
| A | LYS32 |
| A | HIS110 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 904 |
| Chain | Residue |
| A | TYR58 |
| A | LYS62 |
| A | HOH1014 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 905 |
| Chain | Residue |
| A | ARG205 |
| A | LEU211 |
| A | GLY217 |
| A | HOH1028 |
| A | HOH1045 |
| A | HOH1059 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 906 |
| Chain | Residue |
| A | LYS26 |
| A | LYS269 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SAH A 900 |
| Chain | Residue |
| A | PRO16 |
| A | VAL20 |
| A | TYR24 |
| A | THR40 |
| A | TYR41 |
| A | SER42 |
| A | GLY80 |
| A | GLY82 |
| A | THR102 |
| A | LEU103 |
| A | GLN107 |
| A | GLY130 |
| A | TRP131 |
| A | GLU132 |
| A | LEU144 |
| A | GLY145 |
| A | ALA146 |
| A | HIS149 |
| A | 10A901 |
| A | HOH1005 |
| A | HOH1025 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 10A A 901 |
| Chain | Residue |
| A | TYR24 |
| A | TYR41 |
| A | GLY145 |
| A | GLU148 |
| A | ILE184 |
| A | MET201 |
| A | LEU211 |
| A | PHE215 |
| A | TYR247 |
| A | TYR280 |
| A | CYS284 |
| A | LEU287 |
| A | SAH900 |
| A | CO3902 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS284 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11756461 |
| Chain | Residue | Details |
| A | TYR41 | |
| A | LEU76 | |
| A | THR102 | |
| A | TRP131 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:21969609 |
| Chain | Residue | Details |
| A | THR2 |
