Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1KPC

PKCI-1-APO+ZINC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000118	cellular_component	histone deacetylase complex
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0005080	molecular_function	protein kinase C binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006508	biological_process	proteolysis
A	0006915	biological_process	apoptotic process
A	0007165	biological_process	signal transduction
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0009154	biological_process	purine ribonucleotide catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016926	biological_process	protein desumoylation
A	0016929	molecular_function	deSUMOylase activity
A	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
A	0050850	biological_process	positive regulation of calcium-mediated signaling
A	0070062	cellular_component	extracellular exosome
A	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
B	0000118	cellular_component	histone deacetylase complex
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0005080	molecular_function	protein kinase C binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005886	cellular_component	plasma membrane
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006508	biological_process	proteolysis
B	0006915	biological_process	apoptotic process
B	0007165	biological_process	signal transduction
B	0008233	molecular_function	peptidase activity
B	0008234	molecular_function	cysteine-type peptidase activity
B	0009154	biological_process	purine ribonucleotide catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016926	biological_process	protein desumoylation
B	0016929	molecular_function	deSUMOylase activity
B	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
B	0050850	biological_process	positive regulation of calcium-mediated signaling
B	0070062	cellular_component	extracellular exosome
B	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
C	0000118	cellular_component	histone deacetylase complex
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0005080	molecular_function	protein kinase C binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006508	biological_process	proteolysis
C	0006915	biological_process	apoptotic process
C	0007165	biological_process	signal transduction
C	0008233	molecular_function	peptidase activity
C	0008234	molecular_function	cysteine-type peptidase activity
C	0009154	biological_process	purine ribonucleotide catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016926	biological_process	protein desumoylation
C	0016929	molecular_function	deSUMOylase activity
C	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
C	0050850	biological_process	positive regulation of calcium-mediated signaling
C	0070062	cellular_component	extracellular exosome
C	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
D	0000118	cellular_component	histone deacetylase complex
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0005080	molecular_function	protein kinase C binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005886	cellular_component	plasma membrane
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006508	biological_process	proteolysis
D	0006915	biological_process	apoptotic process
D	0007165	biological_process	signal transduction
D	0008233	molecular_function	peptidase activity
D	0008234	molecular_function	cysteine-type peptidase activity
D	0009154	biological_process	purine ribonucleotide catabolic process
D	0016787	molecular_function	hydrolase activity
D	0016926	biological_process	protein desumoylation
D	0016929	molecular_function	deSUMOylase activity
D	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
D	0050850	biological_process	positive regulation of calcium-mediated signaling
D	0070062	cellular_component	extracellular exosome
D	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator

Functional Information from PDB Data

site_id	ZNA
Number of Residues	3
Details	TRIAD OF HISTIDINES POTENTIALLY INVOLVED IN ZINC COORDINATION.

Chain	Residue
A	HIS51
A	HIS112
A	HIS114

site_id	ZNB
Number of Residues	3
Details	TRIAD OF HISTIDINES POTENTIALLY INVOLVED IN ZINC COORDINATION.

Chain	Residue
B	HIS51
B	HIS112
B	HIS114

site_id	ZNC
Number of Residues	3
Details	TRIAD OF HISTIDINES POTENTIALLY INVOLVED IN ZINC COORDINATION.

Chain	Residue
C	HIS51
C	HIS112
C	HIS114

site_id	ZND
Number of Residues	3
Details	TRIAD OF HISTIDINES POTENTIALLY INVOLVED IN ZINC COORDINATION.

Chain	Residue
D	HIS51
D	HIS112
D	HIS114

Functional Information from PROSITE/UniProt

site_id	PS00892
Number of Residues	19
Details	HIT_1 HIT domain signature. NegsdGgQsVyHVHLHVLG

Chain	Residue	Details
A	ASN99-GLY117

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Motif: {"description":"Histidine triad motif"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Tele-AMP-histidine intermediate","evidences":[{"source":"PubMed","id":"9323207","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22869114","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3TW2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P70349","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 5fit

Chain	Residue	Details
A	HIS112
A	ASN99
A	HIS110

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 5fit

Chain	Residue	Details
B	HIS112
B	ASN99
B	HIS110

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 5fit

Chain	Residue	Details
C	HIS112
C	ASN99
C	HIS110

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 5fit

Chain	Residue	Details
D	HIS112
D	ASN99
D	HIS110

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)