Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1KOG

Crystal structure of E. coli threonyl-tRNA synthetase interacting with the essential domain of its mRNA operator

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004829	molecular_function	threonine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006435	biological_process	threonyl-tRNA aminoacylation
B	0000166	molecular_function	nucleotide binding
B	0004812	molecular_function	aminoacyl-tRNA ligase activity
B	0004829	molecular_function	threonine-tRNA ligase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006418	biological_process	tRNA aminoacylation for protein translation
B	0006435	biological_process	threonyl-tRNA aminoacylation
C	0000166	molecular_function	nucleotide binding
C	0004812	molecular_function	aminoacyl-tRNA ligase activity
C	0004829	molecular_function	threonine-tRNA ligase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006418	biological_process	tRNA aminoacylation for protein translation
C	0006435	biological_process	threonyl-tRNA aminoacylation
D	0000166	molecular_function	nucleotide binding
D	0004812	molecular_function	aminoacyl-tRNA ligase activity
D	0004829	molecular_function	threonine-tRNA ligase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006418	biological_process	tRNA aminoacylation for protein translation
D	0006435	biological_process	threonyl-tRNA aminoacylation
E	0000166	molecular_function	nucleotide binding
E	0004812	molecular_function	aminoacyl-tRNA ligase activity
E	0004829	molecular_function	threonine-tRNA ligase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006418	biological_process	tRNA aminoacylation for protein translation
E	0006435	biological_process	threonyl-tRNA aminoacylation
F	0000166	molecular_function	nucleotide binding
F	0004812	molecular_function	aminoacyl-tRNA ligase activity
F	0004829	molecular_function	threonine-tRNA ligase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006418	biological_process	tRNA aminoacylation for protein translation
F	0006435	biological_process	threonyl-tRNA aminoacylation
G	0000166	molecular_function	nucleotide binding
G	0004812	molecular_function	aminoacyl-tRNA ligase activity
G	0004829	molecular_function	threonine-tRNA ligase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006418	biological_process	tRNA aminoacylation for protein translation
G	0006435	biological_process	threonyl-tRNA aminoacylation
H	0000166	molecular_function	nucleotide binding
H	0004812	molecular_function	aminoacyl-tRNA ligase activity
H	0004829	molecular_function	threonine-tRNA ligase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0006418	biological_process	tRNA aminoacylation for protein translation
H	0006435	biological_process	threonyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	CYS334
A	HIS385
A	TYR462
A	HIS511
A	TSB2002

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1

Chain	Residue
B	CYS334
B	HIS385
B	HIS511
B	TSB3002

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 1

Chain	Residue
C	CYS334
C	HIS385
C	TYR462
C	HIS511
C	TSB4002

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1

Chain	Residue
D	CYS334
D	HIS385
D	HIS511
D	TSB5002

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 1

Chain	Residue
E	CYS334
E	HIS385
E	HIS511
E	TSB6002

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN F 1

Chain	Residue
F	CYS334
F	HIS385
F	TYR462
F	HIS511
F	TSB7002

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN G 1

Chain	Residue
G	CYS334
G	HIS385
G	TYR462
G	HIS511
G	TSB8002

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN H 1

Chain	Residue
H	CYS334
H	HIS385
H	TYR462
H	HIS511
H	TSB9002

site_id	AC9
Number of Residues	22
Details	BINDING SITE FOR RESIDUE TSB A 2002

Chain	Residue
A	ZN1
A	MET332
A	CYS334
A	ARG363
A	GLU365
A	MET374
A	VAL376
A	PHE379
A	GLN381
A	ASP383
A	ALA384
A	HIS385
A	TYR462
A	GLN479
A	CYS480
A	THR482
A	GLN484
A	HIS511
A	ARG512
A	GLY516
A	SER517
A	ARG520

site_id	BC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE TSB B 3002

Chain	Residue
B	ZN1
B	MET332
B	CYS334
B	ARG363
B	GLU365
B	MET374
B	VAL376
B	PHE379
B	GLN381
B	ASP383
B	ALA384
B	HIS385
B	TYR462
B	GLN479
B	CYS480
B	THR482
B	GLN484
B	HIS511
B	ARG512
B	GLY516
B	SER517
B	ARG520

site_id	BC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE TSB C 4002

Chain	Residue
C	GLY516
C	SER517
C	ARG520
C	ZN1
C	MET332
C	CYS334
C	ARG363
C	GLU365
C	MET374
C	VAL376
C	PHE379
C	GLN381
C	ASP383
C	ALA384
C	HIS385
C	TYR462
C	GLN479
C	CYS480
C	GLN484
C	HIS511
C	ARG512

site_id	BC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE TSB D 5002

Chain	Residue
D	ZN1
D	MET332
D	CYS334
D	ARG363
D	GLU365
D	MET374
D	VAL376
D	PHE379
D	GLN381
D	ASP383
D	ALA384
D	HIS385
D	TYR462
D	GLN479
D	CYS480
D	THR482
D	GLN484
D	HIS511
D	ARG512
D	GLY516
D	SER517
D	ARG520

site_id	BC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE TSB E 6002

Chain	Residue
E	ZN1
E	MET332
E	CYS334
E	ARG363
E	GLU365
E	MET374
E	VAL376
E	PHE379
E	GLN381
E	ASP383
E	ALA384
E	HIS385
E	TYR462
E	GLN479
E	CYS480
E	THR482
E	GLN484
E	HIS511
E	ARG512
E	ALA513
E	GLY516
E	SER517
E	ARG520

site_id	BC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE TSB F 7002

Chain	Residue
F	ZN1
F	MET332
F	CYS334
F	ARG363
F	GLU365
F	MET374
F	VAL376
F	PHE379
F	GLN381
F	ASP383
F	ALA384
F	HIS385
F	TYR462
F	GLN479
F	CYS480
F	THR482
F	GLN484
F	HIS511
F	ARG512
F	GLY516
F	SER517
F	ARG520

site_id	BC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE TSB G 8002

Chain	Residue
G	ZN1
G	MET332
G	CYS334
G	ARG363
G	GLU365
G	MET374
G	VAL376
G	PHE379
G	GLN381
G	ASP383
G	ALA384
G	HIS385
G	TYR462
G	GLN479
G	CYS480
G	THR482
G	GLN484
G	HIS511
G	ARG512
G	GLY516
G	SER517
G	ARG520

site_id	BC7
Number of Residues	22
Details	BINDING SITE FOR RESIDUE TSB H 9002

Chain	Residue
H	ZN1
H	MET332
H	CYS334
H	ARG363
H	GLU365
H	MET374
H	VAL376
H	PHE379
H	GLN381
H	ASP383
H	ALA384
H	HIS385
H	TYR462
H	GLN479
H	CYS480
H	THR482
H	GLN484
H	HIS511
H	ARG512
H	GLY516
H	SER517
H	ARG520

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2328
Details	Region: {"description":"Catalytic","evidences":[{"source":"HAMAP-Rule","id":"MF_00184","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10319817","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	856
Details	Region: {"description":"Anticodon recognition","evidences":[{"source":"PubMed","id":"10319817","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	288
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11953757","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10319817","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1QF6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	232
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10319817","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00184","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10319817","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10881191","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11136973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11953757","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00184","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10319817","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10881191","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11136973","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"HAMAP-Rule","id":"MF_00184","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
A	ARG363

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
B	ARG363

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
C	ARG363

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
D	ARG363

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
E	ARG363

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
F	ARG363

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
G	ARG363

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
H	ARG363

site_id	MCSA1
Number of Residues	7
Details	M-CSA 540

Chain

Residue

Details

site_id	MCSA2
Number of Residues	7
Details	M-CSA 540

Chain

Residue

Details

site_id	MCSA3
Number of Residues	7
Details	M-CSA 540

Chain

Residue

Details

site_id	MCSA4
Number of Residues	7
Details	M-CSA 540

Chain

Residue

Details

site_id	MCSA5
Number of Residues	7
Details	M-CSA 540

Chain

Residue

Details

site_id	MCSA6
Number of Residues	7
Details	M-CSA 540

Chain

Residue

Details

site_id	MCSA7
Number of Residues	7
Details	M-CSA 540

Chain

Residue

Details

site_id	MCSA8
Number of Residues	7
Details	M-CSA 540

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)