1KO7
X-ray structure of the HPr kinase/phosphatase from Staphylococcus xylosus at 1.95 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000155 | molecular_function | phosphorelay sensor kinase activity |
| A | 0000160 | biological_process | phosphorelay signal transduction system |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006109 | biological_process | regulation of carbohydrate metabolic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000155 | molecular_function | phosphorelay sensor kinase activity |
| B | 0000160 | biological_process | phosphorelay signal transduction system |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006109 | biological_process | regulation of carbohydrate metabolic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 315 |
| Chain | Residue |
| A | ARG33 |
| A | THR55 |
| A | THR56 |
| A | ARG88 |
| A | THR114 |
| A | HOH329 |
| B | TYR45 |
| B | ARG49 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 B 315 |
| Chain | Residue |
| A | ARG250 |
| B | ARG33 |
| B | THR55 |
| B | THR56 |
| B | ARG88 |
| B | THR114 |
| B | HOH319 |
| A | ARG49 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 316 |
| Chain | Residue |
| A | GLY154 |
| A | ILE155 |
| A | GLY156 |
| A | LYS157 |
| A | SER158 |
| A | GLU159 |
| A | PO4317 |
| A | HOH438 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 317 |
| Chain | Residue |
| A | HIS136 |
| A | SER153 |
| A | GLY154 |
| A | LYS157 |
| A | PO4316 |
| A | HOH428 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 B 316 |
| Chain | Residue |
| B | GLY154 |
| B | ILE155 |
| B | GLY156 |
| B | LYS157 |
| B | SER158 |
| B | GLU159 |
| B | ARG202 |
| B | PO4317 |
| B | HOH341 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 317 |
| Chain | Residue |
| B | HIS136 |
| B | SER153 |
| B | LYS157 |
| B | ARG202 |
| B | PO4316 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Region: {"description":"Important for the catalytic mechanism of both phosphorylation and dephosphorylation","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Region: {"description":"Important for the catalytic mechanism of dephosphorylation","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
