1KNC
Structure of AhpD from Mycobacterium tuberculosis, a novel enzyme with thioredoxin-like activity.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0015036 | molecular_function | disulfide oxidoreductase activity |
| A | 0016209 | molecular_function | antioxidant activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0032843 | molecular_function | hydroperoxide reductase activity |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0051920 | molecular_function | peroxiredoxin activity |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0015036 | molecular_function | disulfide oxidoreductase activity |
| B | 0016209 | molecular_function | antioxidant activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0032843 | molecular_function | hydroperoxide reductase activity |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0051920 | molecular_function | peroxiredoxin activity |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0004601 | molecular_function | peroxidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006979 | biological_process | response to oxidative stress |
| C | 0015036 | molecular_function | disulfide oxidoreductase activity |
| C | 0016209 | molecular_function | antioxidant activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0032843 | molecular_function | hydroperoxide reductase activity |
| C | 0045454 | biological_process | cell redox homeostasis |
| C | 0051920 | molecular_function | peroxiredoxin activity |
| C | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 601 |
| Chain | Residue |
| B | ARG68 |
| B | HIS69 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 602 |
| Chain | Residue |
| C | PRO113 |
| C | LYS114 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 603 |
| Chain | Residue |
| B | PRO113 |
| B | HOH626 |
| A | PRO113 |
| A | LYS114 |
| A | HOH650 |
| A | HOH676 |
| A | HOH677 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 B 604 |
| Chain | Residue |
| B | ARG142 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 605 |
| Chain | Residue |
| B | HIS132 |
| B | HOH653 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 606 |
| Chain | Residue |
| B | TYR85 |
| B | ARG88 |
| B | HOH698 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 607 |
| Chain | Residue |
| A | ARG88 |
| A | HIS132 |
| A | HIS139 |
| A | HOH632 |
| A | HOH695 |
| A | HOH741 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 608 |
| Chain | Residue |
| A | GLY89 |
| A | HIS132 |
| A | HOH640 |
| A | HOH641 |
| A | HOH647 |
| A | HOH687 |
| B | ARG94 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 609 |
| Chain | Residue |
| B | PRO113 |
| B | LYS114 |
| B | HOH639 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 610 |
| Chain | Residue |
| C | ARG68 |
| C | HIS69 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 611 |
| Chain | Residue |
| C | GLY89 |
| C | HIS132 |
| C | HOH643 |
| C | HOH646 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 612 |
| Chain | Residue |
| A | ARG99 |
| B | SER64 |
| B | ALA65 |
| B | ARG68 |
| B | HOH712 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 613 |
| Chain | Residue |
| A | ARG103 |
| A | ASN105 |
| A | HOH718 |
| A | HOH737 |
| C | LYS15 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 614 |
| Chain | Residue |
| C | TYR85 |
| C | ARG88 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 615 |
| Chain | Residue |
| B | LYS15 |
| C | ARG103 |
| C | ASN105 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 616 |
| Chain | Residue |
| A | LYS15 |
| B | ARG103 |
| B | ASN105 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 617 |
| Chain | Residue |
| A | SER64 |
| A | ALA65 |
| A | HOH624 |
| B | HOH695 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_01676","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11914371","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01676","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11914371","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
