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1KMC

Crystal Structure of the Caspase-7 / XIAP-BIR2 Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003824molecular_functioncatalytic activity
A0004190molecular_functionaspartic-type endopeptidase activity
A0004197molecular_functioncysteine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0006915biological_processapoptotic process
A0007507biological_processheart development
A0008152biological_processmetabolic process
A0008233molecular_functionpeptidase activity
A0008234molecular_functioncysteine-type peptidase activity
A0009411biological_processresponse to UV
A0016485biological_processprotein processing
A0016787molecular_functionhydrolase activity
A0030163biological_processprotein catabolic process
A0042742biological_processdefense response to bacterium
A0043525biological_processpositive regulation of neuron apoptotic process
A0044346biological_processfibroblast apoptotic process
A0051146biological_processstriated muscle cell differentiation
A0051402biological_processneuron apoptotic process
A0051604biological_processprotein maturation
A0051716biological_processcellular response to stimulus
A0070227biological_processlymphocyte apoptotic process
A0071222biological_processcellular response to lipopolysaccharide
A0071887biological_processleukocyte apoptotic process
A0072734biological_processcellular response to staurosporine
A0097153molecular_functioncysteine-type endopeptidase activity involved in apoptotic process
A0097194biological_processexecution phase of apoptosis
A0097200molecular_functioncysteine-type endopeptidase activity involved in execution phase of apoptosis
A1905686biological_processpositive regulation of plasma membrane repair
B0003723molecular_functionRNA binding
B0003824molecular_functioncatalytic activity
B0004190molecular_functionaspartic-type endopeptidase activity
B0004197molecular_functioncysteine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0006915biological_processapoptotic process
B0007507biological_processheart development
B0008152biological_processmetabolic process
B0008233molecular_functionpeptidase activity
B0008234molecular_functioncysteine-type peptidase activity
B0009411biological_processresponse to UV
B0016485biological_processprotein processing
B0016787molecular_functionhydrolase activity
B0030163biological_processprotein catabolic process
B0042742biological_processdefense response to bacterium
B0043525biological_processpositive regulation of neuron apoptotic process
B0044346biological_processfibroblast apoptotic process
B0051146biological_processstriated muscle cell differentiation
B0051402biological_processneuron apoptotic process
B0051604biological_processprotein maturation
B0051716biological_processcellular response to stimulus
B0070227biological_processlymphocyte apoptotic process
B0071222biological_processcellular response to lipopolysaccharide
B0071887biological_processleukocyte apoptotic process
B0072734biological_processcellular response to staurosporine
B0097153molecular_functioncysteine-type endopeptidase activity involved in apoptotic process
B0097194biological_processexecution phase of apoptosis
B0097200molecular_functioncysteine-type endopeptidase activity involved in execution phase of apoptosis
B1905686biological_processpositive regulation of plasma membrane repair
Functional Information from PROSITE/UniProt
site_idPS01282
Number of Residues68
DetailsBIR_REPEAT_1 BIR repeat. EeaRlksfqn.Wpdyahltprelas.AGLyYtgigDqvqCfcCggklknWepcdrawseHrrhfPnCffV
ChainResidueDetails
CGLU163-VAL230

site_idPS01121
Number of Residues15
DetailsCASPASE_HIS Caspase family histidine active site. HtnaaCfaCiLLSHG
ChainResidueDetails
AHIS224-GLY238

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000269|PubMed:15314233
ChainResidueDetails
AHIS237
BHIS237

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000269|PubMed:11701129, ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:16916640
ChainResidueDetails
AALA285
BALA285

site_idSWS_FT_FI3
Number of Residues6
DetailsSITE: Cleavage; by CAPN1 => ECO:0000269|PubMed:19617626
ChainResidueDetails
APHE129
AMET138
ASER140
BPHE129
BMET138
BSER140

site_idSWS_FT_FI4
Number of Residues4
DetailsSITE: Involved in allosteric regulation => ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:19581639
ChainResidueDetails
AARG286
ATYR331
BARG286
BTYR331

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895
ChainResidueDetails
AALA95
BALA95

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PAK2 => ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:27889207
ChainResidueDetails
ASER123
ASER347
BSER123
BSER347

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER130
BSER130

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PAK2 => ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:27889207
ChainResidueDetails
ATHR272
BTHR272

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: (Microbial infection) ADP-riboxanated arginine => ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120
ChainResidueDetails
AARG341
BARG341

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PDB entries from 2024-04-24

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