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1KK3

Structure of the wild-type large gamma subunit of initiation factor eIF2 from Pyrococcus abyssi complexed with GDP-Mg2+

Functional Information from GO Data
ChainGOidnamespacecontents
A0000049molecular_functiontRNA binding
A0001731biological_processformation of translation preinitiation complex
A0003743molecular_functiontranslation initiation factor activity
A0003746molecular_functiontranslation elongation factor activity
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0005829cellular_componentcytosol
A0006412biological_processtranslation
A0006413biological_processtranslational initiation
A0006414biological_processtranslational elongation
A0016787molecular_functionhydrolase activity
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 411
ChainResidue
ACYS60
ACYS63
ACYS72
ACYS75

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 413
ChainResidue
AHOH1099
ATHR24
AGDP412
AHOH1090
AHOH1091
AHOH1096

site_idAC3
Number of Residues20
DetailsBINDING SITE FOR RESIDUE GDP A 412
ChainResidue
AASP20
AHIS21
AGLY22
ALYS23
ATHR24
ATHR25
AASN145
ALYS146
AGLU148
ALEU149
ASER180
AALA181
ALEU182
AMG413
AHOH1002
AHOH1081
AHOH1088
AHOH1090
AHOH1091
AHOH1099

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q980A5, ECO:0000255|HAMAP-Rule:MF_00119
ChainResidueDetails
AASP20
AGLY45
ATHR47

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00119, ECO:0000269|PubMed:11927566, ECO:0007744|PDB:1KK1, ECO:0007744|PDB:1KK2, ECO:0007744|PDB:1KK3
ChainResidueDetails
ATHR24
AASN145
ASER180

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00119, ECO:0000269|PubMed:11927566, ECO:0007744|PDB:1KJZ, ECO:0007744|PDB:1KK0, ECO:0007744|PDB:1KK1, ECO:0007744|PDB:1KK2, ECO:0007744|PDB:1KK3
ChainResidueDetails
ACYS60
ACYS63
ACYS72
ACYS75

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AASP20

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AHIS93

224201

PDB entries from 2024-08-28

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