1KK2

Structure of the large gamma subunit of initiation factor eIF2 from Pyrococcus abyssi-G235D mutant complexed with GDP-Mg2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0001731	biological_process	formation of translation preinitiation complex
A	0003743	molecular_function	translation initiation factor activity
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006414	biological_process	translational elongation
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 411

Chain	Residue
A	CYS60
A	CYS63
A	CYS72
A	CYS75

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 413

Chain	Residue
A	HOH1093
A	THR24
A	GDP412
A	HOH1086
A	HOH1087
A	HOH1090

---

site_id	AC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE GDP A 412

Chain	Residue
A	VAL19
A	ASP20
A	HIS21
A	GLY22
A	LYS23
A	THR24
A	THR25
A	ASN145
A	LYS146
A	GLU148
A	LEU149
A	SER180
A	ALA181
A	LEU182
A	MG413
A	HOH1002
A	HOH1084
A	HOH1086
A	HOH1087
A	HOH1093
A	HOH1159

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Region: {"description":"G1","evidences":[{"source":"UniProtKB","id":"Q980A5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Region: {"description":"G2","evidences":[{"source":"UniProtKB","id":"Q980A5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Region: {"description":"G3","evidences":[{"source":"UniProtKB","id":"Q980A5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Region: {"description":"G4","evidences":[{"source":"UniProtKB","id":"Q980A5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Region: {"description":"G5","evidences":[{"source":"UniProtKB","id":"Q980A5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11927566","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KK1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KK3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q980A5","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11927566","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KJZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KK0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KK1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KK3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	ASP20

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	HIS93

---