1KHZ
Structure of the ADPR-ase in complex with AMPCPR and Mg
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006753 | biological_process | nucleoside phosphate metabolic process |
| A | 0009408 | biological_process | response to heat |
| A | 0016462 | molecular_function | pyrophosphatase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016818 | molecular_function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| A | 0019144 | molecular_function | ADP-sugar diphosphatase activity |
| A | 0019693 | biological_process | ribose phosphate metabolic process |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006753 | biological_process | nucleoside phosphate metabolic process |
| B | 0009408 | biological_process | response to heat |
| B | 0016462 | molecular_function | pyrophosphatase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016818 | molecular_function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| B | 0019144 | molecular_function | ADP-sugar diphosphatase activity |
| B | 0019693 | biological_process | ribose phosphate metabolic process |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 401 |
| Chain | Residue |
| B | ARG50 |
| B | GLU207 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG B 301 |
| Chain | Residue |
| B | HOH407 |
| B | GLU112 |
| B | GLU116 |
| B | GLU164 |
| B | MG304 |
| B | MG310 |
| B | ADV402 |
| B | HOH403 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG B 304 |
| Chain | Residue |
| B | GLU112 |
| B | GLU162 |
| B | MG301 |
| B | ADV402 |
| B | HOH404 |
| B | HOH405 |
| B | HOH406 |
| B | HOH407 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 310 |
| Chain | Residue |
| B | ALA96 |
| B | GLU116 |
| B | MG301 |
| B | ADV402 |
| B | HOH409 |
| B | HOH410 |
| site_id | AC5 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE ADV B 402 |
| Chain | Residue |
| A | ARG51 |
| A | GLU52 |
| A | SER133 |
| A | PRO134 |
| A | GLY135 |
| B | PHE28 |
| B | PHE29 |
| B | ARG56 |
| B | ARG79 |
| B | ALA96 |
| B | GLY97 |
| B | MET98 |
| B | GLU112 |
| B | GLU116 |
| B | GLU139 |
| B | GLU162 |
| B | GLU164 |
| B | MG301 |
| B | MG304 |
| B | MG310 |
| B | HOH405 |
| B | HOH407 |
| B | HOH408 |
| B | HOH409 |
| B | HOH436 |
| B | HOH489 |
| B | HOH501 |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GmieegEsvedVArREAiEEaG |
| Chain | Residue | Details |
| A | GLY97-GLY118 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305 |
| Chain | Residue | Details |
| A | GLU162 | |
| B | GLU162 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: in other chain |
| Chain | Residue | Details |
| A | PHE28 | |
| B | GLU139 | |
| A | ARG56 | |
| A | ARG79 | |
| A | MET98 | |
| A | GLU139 | |
| B | PHE28 | |
| B | ARG56 | |
| B | ARG79 | |
| B | MET98 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG51 | |
| B | GLU116 | |
| B | SER133 | |
| B | GLU164 | |
| A | ALA96 | |
| A | GLU112 | |
| A | GLU116 | |
| A | SER133 | |
| A | GLU164 | |
| B | ARG51 | |
| B | ALA96 | |
| B | GLU112 |
