1KGI

Rat transthyretin (also called prealbumin) complex with 3,3',5,5'-tetraiodothyroacetic acid (t4ac)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001523	biological_process	retinoid metabolic process
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006144	biological_process	purine nucleobase metabolic process
A	0007165	biological_process	signal transduction
A	0032991	cellular_component	protein-containing complex
A	0036094	molecular_function	small molecule binding
A	0042403	biological_process	thyroid hormone metabolic process
A	0042562	molecular_function	hormone binding
A	0042802	molecular_function	identical protein binding
A	0044877	molecular_function	protein-containing complex binding
A	0070324	molecular_function	thyroid hormone binding
A	0140313	molecular_function	molecular sequestering activity
B	0001523	biological_process	retinoid metabolic process
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006144	biological_process	purine nucleobase metabolic process
B	0007165	biological_process	signal transduction
B	0032991	cellular_component	protein-containing complex
B	0036094	molecular_function	small molecule binding
B	0042403	biological_process	thyroid hormone metabolic process
B	0042562	molecular_function	hormone binding
B	0042802	molecular_function	identical protein binding
B	0044877	molecular_function	protein-containing complex binding
B	0070324	molecular_function	thyroid hormone binding
B	0140313	molecular_function	molecular sequestering activity
C	0001523	biological_process	retinoid metabolic process
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006144	biological_process	purine nucleobase metabolic process
C	0007165	biological_process	signal transduction
C	0032991	cellular_component	protein-containing complex
C	0036094	molecular_function	small molecule binding
C	0042403	biological_process	thyroid hormone metabolic process
C	0042562	molecular_function	hormone binding
C	0042802	molecular_function	identical protein binding
C	0044877	molecular_function	protein-containing complex binding
C	0070324	molecular_function	thyroid hormone binding
C	0140313	molecular_function	molecular sequestering activity
D	0001523	biological_process	retinoid metabolic process
D	0005179	molecular_function	hormone activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006144	biological_process	purine nucleobase metabolic process
D	0007165	biological_process	signal transduction
D	0032991	cellular_component	protein-containing complex
D	0036094	molecular_function	small molecule binding
D	0042403	biological_process	thyroid hormone metabolic process
D	0042562	molecular_function	hormone binding
D	0042802	molecular_function	identical protein binding
D	0044877	molecular_function	protein-containing complex binding
D	0070324	molecular_function	thyroid hormone binding
D	0140313	molecular_function	molecular sequestering activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE T4A C 128

Chain	Residue
A	LYS15
C	LEU417
C	ALA508
C	ALA509
C	SER517
C	THR518
C	THR519
C	HOH972
C	HOH973
D	SER715
A	LEU17
A	THR106
A	ALA108
A	ALA109
A	LEU110
A	SER117
A	THR119
C	LYS415

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE T4A D 328

Chain	Residue
B	LYS215
B	LEU217
B	GLU254
B	ALA308
B	ALA309
B	LEU310
D	LYS615
D	LEU617
D	GLU654
D	ALA708
D	ALA709
D	LEU710
D	HOH995

---

Functional Information from PROSITE/UniProt

site_id	PS00768
Number of Residues	16
Details	TRANSTHYRETIN_1 Transthyretin signature 1. KVLDavrGsPAvdVaV

Chain	Residue	Details
A	LYS15-VAL30

---

site_id	PS00769
Number of Residues	13
Details	TRANSTHYRETIN_2 Transthyretin signature 2. YTIAalLSPYSYS

Chain	Residue	Details
A	TYR105-SER117

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11995998","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1KGI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11995998","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Sulfocysteine","evidences":[{"source":"UniProtKB","id":"P02766","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"4-carboxyglutamate","evidences":[{"source":"UniProtKB","id":"P02766","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---