Functional Information from GO Data
| Chain | GOid | namespace | contents |
| L | 0000785 | cellular_component | chromatin |
| L | 0001666 | biological_process | response to hypoxia |
| L | 0001824 | biological_process | blastocyst development |
| L | 0004198 | molecular_function | calcium-dependent cysteine-type endopeptidase activity |
| L | 0005509 | molecular_function | calcium ion binding |
| L | 0005515 | molecular_function | protein binding |
| L | 0005634 | cellular_component | nucleus |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0005764 | cellular_component | lysosome |
| L | 0005783 | cellular_component | endoplasmic reticulum |
| L | 0005794 | cellular_component | Golgi apparatus |
| L | 0005829 | cellular_component | cytosol |
| L | 0005886 | cellular_component | plasma membrane |
| L | 0005925 | cellular_component | focal adhesion |
| L | 0006508 | biological_process | proteolysis |
| L | 0007520 | biological_process | myoblast fusion |
| L | 0007565 | biological_process | female pregnancy |
| L | 0008092 | molecular_function | cytoskeletal protein binding |
| L | 0008233 | molecular_function | peptidase activity |
| L | 0008234 | molecular_function | cysteine-type peptidase activity |
| L | 0009612 | biological_process | response to mechanical stimulus |
| L | 0009897 | cellular_component | external side of plasma membrane |
| L | 0010666 | biological_process | positive regulation of cardiac muscle cell apoptotic process |
| L | 0016540 | biological_process | protein autoprocessing |
| L | 0016787 | molecular_function | hydrolase activity |
| L | 0019899 | molecular_function | enzyme binding |
| L | 0030163 | biological_process | protein catabolic process |
| L | 0030425 | cellular_component | dendrite |
| L | 0030864 | cellular_component | cortical actin cytoskeleton |
| L | 0031143 | cellular_component | pseudopodium |
| L | 0032675 | biological_process | regulation of interleukin-6 production |
| L | 0035458 | biological_process | cellular response to interferon-beta |
| L | 0042542 | biological_process | response to hydrogen peroxide |
| L | 0042995 | cellular_component | cell projection |
| L | 0043025 | cellular_component | neuronal cell body |
| L | 0044877 | molecular_function | protein-containing complex binding |
| L | 0045121 | cellular_component | membrane raft |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0048266 | biological_process | behavioral response to pain |
| L | 0048488 | biological_process | synaptic vesicle endocytosis |
| L | 0051493 | biological_process | regulation of cytoskeleton organization |
| L | 0051603 | biological_process | proteolysis involved in protein catabolic process |
| L | 0070062 | cellular_component | extracellular exosome |
| L | 0071222 | biological_process | cellular response to lipopolysaccharide |
| L | 0071230 | biological_process | cellular response to amino acid stimulus |
| L | 0097038 | cellular_component | perinuclear endoplasmic reticulum |
| L | 0097225 | cellular_component | sperm midpiece |
| L | 0097228 | cellular_component | sperm principal piece |
| L | 0097700 | biological_process | vascular endothelial cell response to laminar fluid shear stress |
| L | 0097706 | biological_process | vascular endothelial cell response to oscillatory fluid shear stress |
| L | 0098793 | cellular_component | presynapse |
| L | 0098794 | cellular_component | postsynapse |
| L | 0110158 | cellular_component | calpain complex |
| L | 0120212 | cellular_component | sperm head-tail coupling apparatus |
| L | 0140249 | biological_process | protein catabolic process at postsynapse |
| L | 1901741 | biological_process | positive regulation of myoblast fusion |
| L | 2001247 | biological_process | positive regulation of phosphatidylcholine biosynthetic process |
| S | 0005509 | molecular_function | calcium ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DSDTTGKLGfeEF |
| Chain | Residue | Details |
| S | ASP852-PHE864 | |
| S | ASP882-LEU894 | |
| L | ASP585-PHE597 | |
| L | ASP615-MET627 |
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGaLGDCWLlAA |
| Chain | Residue | Details |
| L | GLN99-ALA110 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 17 |
| Details | Propeptide: {"description":"Anchors to the small subunit","featureId":"PRO_0000026487","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 299 |
| Details | Domain: {"description":"Calpain catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00239","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 33 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 68 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 68 |
| Details | Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 169 |
| Details | Region: {"description":"Domain III"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 14 |
| Details | Region: {"description":"Linker"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 170 |
| Details | Region: {"description":"Domain IV"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 34 |
| Details | Domain: {"description":"EF-hand 1; atypical","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 28 |
| Details | Domain: {"description":"EF-hand 4","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 34 |
| Details | Domain: {"description":"EF-hand 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q64537","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q64537","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | a catalytic site defined by CSA, PubMed 10639123 |
| Chain | Residue | Details |
| L | CYS105 | |
| L | CYS105 | |
| L | HIS262 | |
| L | ASN286 | |
| L | GLN99 | |
| L | TRP288 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 589 |
| Chain | Residue | Details |
