1KF6
E. coli Quinol-Fumarate Reductase with Bound Inhibitor HQNO
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000104 | molecular_function | succinate dehydrogenase activity |
A | 0000166 | molecular_function | nucleotide binding |
A | 0005515 | molecular_function | protein binding |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006113 | biological_process | fermentation |
A | 0006974 | biological_process | DNA damage response |
A | 0008177 | molecular_function | succinate dehydrogenase (quinone) activity |
A | 0009055 | molecular_function | electron transfer activity |
A | 0009061 | biological_process | anaerobic respiration |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
A | 0019645 | biological_process | anaerobic electron transport chain |
A | 0022900 | biological_process | electron transport chain |
A | 0044780 | biological_process | bacterial-type flagellum assembly |
A | 0045284 | cellular_component | obsolete plasma membrane fumarate reductase complex |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0071949 | molecular_function | FAD binding |
B | 0005515 | molecular_function | protein binding |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0006099 | biological_process | tricarboxylic acid cycle |
B | 0006113 | biological_process | fermentation |
B | 0008177 | molecular_function | succinate dehydrogenase (quinone) activity |
B | 0009055 | molecular_function | electron transfer activity |
B | 0009061 | biological_process | anaerobic respiration |
B | 0016020 | cellular_component | membrane |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0019645 | biological_process | anaerobic electron transport chain |
B | 0044780 | biological_process | bacterial-type flagellum assembly |
B | 0045284 | cellular_component | obsolete plasma membrane fumarate reductase complex |
B | 0046872 | molecular_function | metal ion binding |
B | 0051536 | molecular_function | iron-sulfur cluster binding |
B | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
B | 0051538 | molecular_function | 3 iron, 4 sulfur cluster binding |
B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
C | 0000104 | molecular_function | succinate dehydrogenase activity |
C | 0005886 | cellular_component | plasma membrane |
C | 0006113 | biological_process | fermentation |
C | 0009061 | biological_process | anaerobic respiration |
C | 0016020 | cellular_component | membrane |
C | 0019645 | biological_process | anaerobic electron transport chain |
C | 0044780 | biological_process | bacterial-type flagellum assembly |
C | 0045284 | cellular_component | obsolete plasma membrane fumarate reductase complex |
D | 0000104 | molecular_function | succinate dehydrogenase activity |
D | 0005886 | cellular_component | plasma membrane |
D | 0006106 | biological_process | fumarate metabolic process |
D | 0006113 | biological_process | fermentation |
D | 0009061 | biological_process | anaerobic respiration |
D | 0016020 | cellular_component | membrane |
D | 0019645 | biological_process | anaerobic electron transport chain |
D | 0044780 | biological_process | bacterial-type flagellum assembly |
D | 0045284 | cellular_component | obsolete plasma membrane fumarate reductase complex |
M | 0000104 | molecular_function | succinate dehydrogenase activity |
M | 0000166 | molecular_function | nucleotide binding |
M | 0005515 | molecular_function | protein binding |
M | 0005829 | cellular_component | cytosol |
M | 0005886 | cellular_component | plasma membrane |
M | 0006113 | biological_process | fermentation |
M | 0006974 | biological_process | DNA damage response |
M | 0008177 | molecular_function | succinate dehydrogenase (quinone) activity |
M | 0009055 | molecular_function | electron transfer activity |
M | 0009061 | biological_process | anaerobic respiration |
M | 0016020 | cellular_component | membrane |
M | 0016491 | molecular_function | oxidoreductase activity |
M | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
M | 0019645 | biological_process | anaerobic electron transport chain |
M | 0022900 | biological_process | electron transport chain |
M | 0044780 | biological_process | bacterial-type flagellum assembly |
M | 0045284 | cellular_component | obsolete plasma membrane fumarate reductase complex |
M | 0050660 | molecular_function | flavin adenine dinucleotide binding |
M | 0071949 | molecular_function | FAD binding |
N | 0005515 | molecular_function | protein binding |
N | 0005829 | cellular_component | cytosol |
N | 0005886 | cellular_component | plasma membrane |
N | 0006099 | biological_process | tricarboxylic acid cycle |
N | 0006113 | biological_process | fermentation |
N | 0008177 | molecular_function | succinate dehydrogenase (quinone) activity |
N | 0009055 | molecular_function | electron transfer activity |
N | 0009061 | biological_process | anaerobic respiration |
N | 0016020 | cellular_component | membrane |
N | 0016491 | molecular_function | oxidoreductase activity |
N | 0019645 | biological_process | anaerobic electron transport chain |
N | 0044780 | biological_process | bacterial-type flagellum assembly |
N | 0045284 | cellular_component | obsolete plasma membrane fumarate reductase complex |
N | 0046872 | molecular_function | metal ion binding |
N | 0051536 | molecular_function | iron-sulfur cluster binding |
N | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
N | 0051538 | molecular_function | 3 iron, 4 sulfur cluster binding |
N | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
O | 0000104 | molecular_function | succinate dehydrogenase activity |
O | 0005886 | cellular_component | plasma membrane |
O | 0006113 | biological_process | fermentation |
O | 0009061 | biological_process | anaerobic respiration |
O | 0016020 | cellular_component | membrane |
O | 0019645 | biological_process | anaerobic electron transport chain |
O | 0044780 | biological_process | bacterial-type flagellum assembly |
O | 0045284 | cellular_component | obsolete plasma membrane fumarate reductase complex |
P | 0000104 | molecular_function | succinate dehydrogenase activity |
P | 0005886 | cellular_component | plasma membrane |
P | 0006106 | biological_process | fumarate metabolic process |
P | 0006113 | biological_process | fermentation |
P | 0009061 | biological_process | anaerobic respiration |
P | 0016020 | cellular_component | membrane |
P | 0019645 | biological_process | anaerobic electron transport chain |
P | 0044780 | biological_process | bacterial-type flagellum assembly |
P | 0045284 | cellular_component | obsolete plasma membrane fumarate reductase complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K A 720 |
Chain | Residue |
A | THR357 |
A | MET358 |
A | GLY359 |
A | GLU379 |
A | SER381 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K M 820 |
Chain | Residue |
M | SER381 |
M | THR357 |
M | MET358 |
M | GLY359 |
M | GLU379 |
site_id | AC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE OAA A 702 |
Chain | Residue |
A | HIS232 |
A | LEU242 |
A | THR244 |
A | GLU245 |
A | HIS355 |
A | ARG390 |
A | GLY392 |
A | SER393 |
A | FAD721 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ACT A 703 |
Chain | Residue |
A | ASP556 |
A | ARG562 |
A | GLU564 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ACT B 704 |
Chain | Residue |
A | ARG452 |
B | GLY41 |
B | ASP45 |
site_id | AC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE OAA M 802 |
Chain | Residue |
M | PHE116 |
M | HIS232 |
M | LEU242 |
M | THR244 |
M | GLU245 |
M | ARG287 |
M | HIS355 |
M | ARG390 |
M | SER393 |
M | FAD821 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ACT N 803 |
Chain | Residue |
M | TRP448 |
M | ARG452 |
N | GLY41 |
N | ASP45 |
N | TYR53 |
N | TRP55 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE FES B 244 |
Chain | Residue |
B | SER56 |
B | CYS57 |
B | ARG58 |
B | CYS62 |
B | GLY63 |
B | CYS65 |
B | CYS77 |
site_id | AC9 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE F3S B 245 |
Chain | Residue |
B | CYS158 |
B | GLN160 |
B | CYS204 |
B | THR205 |
B | PHE206 |
B | VAL207 |
B | GLY208 |
B | TYR209 |
B | CYS210 |
B | ILE224 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SF4 B 246 |
Chain | Residue |
B | CYS148 |
B | ILE149 |
B | CYS151 |
B | GLY152 |
B | CYS154 |
B | CYS214 |
site_id | BC2 |
Number of Residues | 32 |
Details | BINDING SITE FOR RESIDUE FAD A 721 |
Chain | Residue |
A | GLY11 |
A | ALA12 |
A | GLY14 |
A | ALA15 |
A | SER36 |
A | LYS37 |
A | VAL38 |
A | SER43 |
A | HIS44 |
A | THR45 |
A | ALA48 |
A | GLU49 |
A | GLY50 |
A | GLY51 |
A | HIS155 |
A | VAL157 |
A | ALA191 |
A | THR192 |
A | GLY193 |
A | THR203 |
A | ASN204 |
A | ASP211 |
A | HIS355 |
A | TYR356 |
A | GLU379 |
A | ARG390 |
A | SER393 |
A | ASN394 |
A | SER395 |
A | LEU396 |
A | LEU399 |
A | OAA702 |
site_id | BC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE FES N 244 |
Chain | Residue |
N | CYS62 |
N | GLY63 |
N | CYS65 |
N | CYS77 |
N | SER56 |
N | CYS57 |
N | ARG58 |
site_id | BC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE F3S N 245 |
Chain | Residue |
N | CYS158 |
N | GLN160 |
N | CYS204 |
N | THR205 |
N | PHE206 |
N | VAL207 |
N | GLY208 |
N | CYS210 |
N | ILE224 |
site_id | BC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SF4 N 246 |
Chain | Residue |
N | CYS148 |
N | ILE149 |
N | ASN150 |
N | CYS151 |
N | GLY152 |
N | CYS154 |
N | CYS214 |
N | VAL218 |
site_id | BC6 |
Number of Residues | 36 |
Details | BINDING SITE FOR RESIDUE FAD M 821 |
Chain | Residue |
M | GLY11 |
M | ALA12 |
M | GLY13 |
M | GLY14 |
M | ALA15 |
M | SER36 |
M | LYS37 |
M | VAL38 |
M | SER43 |
M | HIS44 |
M | THR45 |
M | ALA48 |
M | GLU49 |
M | GLY50 |
M | GLY51 |
M | HIS155 |
M | PHE156 |
M | VAL157 |
M | ALA191 |
M | THR192 |
M | GLY193 |
M | THR203 |
M | ASN204 |
M | ASP211 |
M | LEU242 |
M | HIS355 |
M | TYR356 |
M | GLY378 |
M | GLU379 |
M | ARG390 |
M | SER393 |
M | ASN394 |
M | SER395 |
M | LEU396 |
M | LEU399 |
M | OAA802 |
site_id | BC7 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE HQO C 700 |
Chain | Residue |
B | THR205 |
B | PHE206 |
B | GLN225 |
B | LYS228 |
C | ARG28 |
C | GLU29 |
D | TRP14 |
D | PHE17 |
D | HIS80 |
site_id | BC8 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE CE1 P 710 |
Chain | Residue |
B | THR239 |
D | TRP76 |
P | ASP9 |
P | LYS97 |
P | TRP98 |
P | TYR101 |
P | GLY102 |
P | CE1810 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CE1 P 810 |
Chain | Residue |
D | ASP9 |
D | TRP98 |
P | ASP9 |
P | PHE13 |
P | TRP76 |
P | CE1710 |
site_id | CC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE CE1 O 811 |
Chain | Residue |
C | TYR129 |
D | LEU43 |
D | PHE44 |
D | PRO45 |
D | GLY46 |
O | LEU73 |
O | CE1813 |
site_id | CC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE CE1 O 812 |
Chain | Residue |
C | VAL98 |
C | PRO107 |
C | SER111 |
C | ALA114 |
C | VAL118 |
O | LEU124 |
O | TYR129 |
P | PRO45 |
site_id | CC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CE1 O 813 |
Chain | Residue |
C | TYR129 |
O | ARG23 |
O | PHE24 |
O | GLY30 |
O | CE1811 |
site_id | CC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE 1PE A 705 |
Chain | Residue |
A | GLY72 |
A | ARG287 |
A | ASP288 |
A | LYS289 |
A | GLN292 |
A | TYR466 |
A | GLN533 |
site_id | CC5 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE HQO N 800 |
Chain | Residue |
N | THR205 |
N | PHE206 |
N | GLN225 |
N | LYS228 |
O | ARG28 |
O | GLU29 |
P | TRP14 |
P | PHE17 |
P | ARG81 |
Functional Information from PROSITE/UniProt
site_id | PS00197 |
Number of Residues | 9 |
Details | 2FE2S_FER_1 2Fe-2S ferredoxin-type iron-sulfur binding region signature. CRMAICGSC |
Chain | Residue | Details |
B | CYS57-CYS65 |
site_id | PS00198 |
Number of Residues | 12 |
Details | 4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiNCGlCYaACP |
Chain | Residue | Details |
B | CYS148-PRO159 |
site_id | PS00504 |
Number of Residues | 10 |
Details | FRD_SDH_FAD_BINDING Fumarate reductase / succinate dehydrogenase FAD-binding site. RSHTvaAeGG |
Chain | Residue | Details |
A | ARG42-GLY51 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 26 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:10373108 |
Chain | Residue | Details |
D | MET0-ARG7 | |
D | LEU89-ALA95 | |
P | MET0-ARG7 | |
P | LEU89-ALA95 | |
O | ASN65-LEU89 | |
O | GLY104-ALA127 |
site_id | SWS_FT_FI2 |
Number of Residues | 144 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:10373108 |
Chain | Residue | Details |
D | SER8-LEU34 | |
B | SER211 | |
B | PRO215 | |
N | ARG58 | |
N | GLY63 | |
N | GLY66 | |
N | LYS78 | |
N | ILE149 | |
N | GLY152 | |
N | TYR155 | |
N | PRO159 | |
D | SER60-ASP88 | |
N | THR205 | |
N | SER211 | |
N | PRO215 | |
D | GLY96-GLY114 | |
P | SER8-LEU34 | |
P | SER60-ASP88 | |
P | GLY96-GLY114 | |
B | TYR155 | |
B | PRO159 | |
B | THR205 |
site_id | SWS_FT_FI3 |
Number of Residues | 48 |
Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:10373108 |
Chain | Residue | Details |
D | VAL35-GLN59 | |
P | VAL35-GLN59 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:10373108, ECO:0000269|PubMed:15919996 |
Chain | Residue | Details |
D | VAL115-ILE118 | |
P | VAL115-ILE118 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0007744|PDB:1L0V |
Chain | Residue | Details |
D | TRP14 | |
P | TRP14 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0007744|PDB:1L0V |
Chain | Residue | Details |
C | TRP86 | |
O | TRP86 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1d4c |
Chain | Residue | Details |
A | ARG287 | |
A | HIS355 | |
A | ARG390 | |
A | HIS232 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1d4c |
Chain | Residue | Details |
M | ARG287 | |
M | HIS355 | |
M | ARG390 | |
M | HIS232 |