1KEA
STRUCTURE OF A THERMOSTABLE THYMINE-DNA GLYCOSYLASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000701 | molecular_function | purine-specific mismatch base pair DNA N-glycosylase activity |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0006281 | biological_process | DNA repair |
| A | 0006284 | biological_process | base-excision repair |
| A | 0006298 | biological_process | mismatch repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0019104 | molecular_function | DNA N-glycosylase activity |
| A | 0032357 | molecular_function | oxidized purine DNA binding |
| A | 0034039 | molecular_function | 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity |
| A | 0035485 | molecular_function | adenine/guanine mispair binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| A | 0141016 | molecular_function | G/T mismatch-specific thymine-DNA glycosylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 1001 |
| Chain | Residue |
| A | HIS31 |
| A | CYS66 |
| A | GLU68 |
| A | CL2001 |
| A | ACT3004 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 3001 |
| Chain | Residue |
| A | GLY124 |
| A | LYS125 |
| A | ACT3002 |
| A | HOH5063 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 3002 |
| Chain | Residue |
| A | SER14 |
| A | TYR164 |
| A | ACT3001 |
| A | HOH5148 |
| A | HOH5186 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 3003 |
| Chain | Residue |
| A | GLN90 |
| A | LYS139 |
| A | GLY179 |
| A | HOH5133 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT A 3004 |
| Chain | Residue |
| A | GLU68 |
| A | ARG109 |
| A | ARG183 |
| A | ZN1001 |
| A | CL2001 |
| A | HOH5056 |
| A | HOH5191 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 2001 |
| Chain | Residue |
| A | CYS66 |
| A | GLU68 |
| A | ZN1001 |
| A | ACT3004 |
| A | HOH5025 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 2002 |
| Chain | Residue |
| A | ARG33 |
| A | TYR36 |
| A | VAL110 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SF4 A 300 |
| Chain | Residue |
| A | CYS197 |
| A | CYS204 |
| A | CYS207 |
| A | MET209 |
| A | SER210 |
| A | CYS213 |
| A | TYR215 |
Functional Information from PROSITE/UniProt
| site_id | PS00764 |
| Number of Residues | 17 |
| Details | ENDONUCLEASE_III_1 Endonuclease III iron-sulfur binding region signature. CaprKPKCekCgmsklC |
| Chain | Residue | Details |
| A | CYS197-CYS213 |
| site_id | PS01155 |
| Number of Residues | 30 |
| Details | ENDONUCLEASE_III_2 Endonuclease III family signature. GrVPrnrkaIld.LPGVGkytCaavMclAFG |
| Chain | Residue | Details |
| A | GLY108-GLY137 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | Domain: {"description":"HhH"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P83847","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2abk |
| Chain | Residue | Details |
| A | TYR126 | |
| A | ASP144 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2abk |
| Chain | Residue | Details |
| A | GLU42 | |
| A | ASP144 |
