1KB4
Crystal Structure of VDR DNA-binding Domain Bound to a Canonical Direct Repeat with Three Base Pair Spacer (DR3) Response Element
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 150 |
| Chain | Residue |
| A | CYS24 |
| A | CYS27 |
| A | CYS41 |
| A | CYS44 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 151 |
| Chain | Residue |
| A | CYS60 |
| A | CYS66 |
| A | CYS76 |
| A | CYS79 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 350 |
| Chain | Residue |
| B | CYS227 |
| B | CYS241 |
| B | CYS244 |
| B | CYS224 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 351 |
| Chain | Residue |
| B | CYS260 |
| B | CYS266 |
| B | CYS276 |
| B | CYS279 |
Functional Information from PROSITE/UniProt
| site_id | PS00031 |
| Number of Residues | 27 |
| Details | NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CgvCg.Dratgf.HFnamtCegCkgFFrR |
| Chain | Residue | Details |
| A | CYS24-ARG50 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 88 |
| Details | Zinc finger: {"description":"NR C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00407","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11980721","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15225774","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KB6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YNW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
