1KAP

THREE-DIMENSIONAL STRUCTURE OF THE ALKALINE PROTEASE OF PSEUDOMONAS AERUGINOSA: A TWO-DOMAIN PROTEIN WITH A CALCIUM BINDING PARALLEL BETA ROLL MOTIF

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0001869	biological_process	negative regulation of complement activation, lectin pathway
P	0004222	molecular_function	metalloendopeptidase activity
P	0005509	molecular_function	calcium ion binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0006508	biological_process	proteolysis
P	0008233	molecular_function	peptidase activity
P	0008237	molecular_function	metallopeptidase activity
P	0008270	molecular_function	zinc ion binding
P	0010765	biological_process	positive regulation of sodium ion transport
P	0016787	molecular_function	hydrolase activity
P	0031012	cellular_component	extracellular matrix
P	0045959	biological_process	negative regulation of complement activation, classical pathway
P	0046872	molecular_function	metal ion binding
P	0141141	biological_process	symbiont-mediated evasion of recognition by host pattern recognition receptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P 613

Chain	Residue
I	SER754
P	HIS176
P	HIS180
P	HIS186

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P 614

Chain	Residue
P	ASP290
P	ARG253
P	GLY255
P	THR257
P	ASP285
P	GLY287

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P 615

Chain	Residue
P	GLY288
P	ASP290
P	THR327
P	GLU329
P	HOH538
P	HOH591

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P 616

Chain	Residue
P	GLY334
P	GLY336
P	ASP338
P	GLY351
P	ALA353
P	ASP356

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P 617

Chain	Residue
P	GLY370
P	GLY372
P	ASP374
P	ASP400
P	HOH548
P	HOH608

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P 618

Chain	Residue
P	ASN343
P	VAL345
P	ASN347
P	GLY360
P	LEU362
P	ASP365

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P 619

Chain	Residue
P	GLY361
P	GLY363
P	ASP365
P	GLU383
P	ASP390
P	HOH544

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P 620

Chain	Residue
P	GLY352
P	GLY354
P	ASP356
P	GLY369
P	ALA371
P	ASP374

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P 621

Chain	Residue
P	ASP446
P	SER448
P	ASP450
P	HIS452
P	ASP454
P	HOH692

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TLTHEIGHTL

Chain	Residue	Details
P	THR173-LEU182

---

site_id	PS00330
Number of Residues	19
Details	HEMOLYSIN_CALCIUM Hemolysin-type calcium-binding region signature. DiLygglGaDqLwGGagaD

Chain	Residue	Details
P	ASP356-ASP374

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	13
Details	Repeat: {"description":"Hemolysin-type calcium-binding 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Repeat: {"description":"Hemolysin-type calcium-binding 2","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	17
Details	Repeat: {"description":"Hemolysin-type calcium-binding 3","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	41
Details	Binding site: {}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
P	GLU177
P	GLU194

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
P	GLU177

---