1K9S
PURINE NUCLEOSIDE PHOSPHORYLASE FROM E. COLI IN COMPLEX WITH FORMYCIN A DERIVATIVE AND PHOSPHATE
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
A | 0006152 | biological_process | purine nucleoside catabolic process |
A | 0006974 | biological_process | DNA damage response |
A | 0009116 | biological_process | nucleoside metabolic process |
A | 0009164 | biological_process | nucleoside catabolic process |
A | 0016020 | cellular_component | membrane |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0016763 | molecular_function | pentosyltransferase activity |
A | 0019686 | biological_process | purine nucleoside interconversion |
A | 0042278 | biological_process | purine nucleoside metabolic process |
A | 0042802 | molecular_function | identical protein binding |
A | 0047975 | molecular_function | guanosine phosphorylase activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
B | 0006152 | biological_process | purine nucleoside catabolic process |
B | 0006974 | biological_process | DNA damage response |
B | 0009116 | biological_process | nucleoside metabolic process |
B | 0009164 | biological_process | nucleoside catabolic process |
B | 0016020 | cellular_component | membrane |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0016763 | molecular_function | pentosyltransferase activity |
B | 0019686 | biological_process | purine nucleoside interconversion |
B | 0042278 | biological_process | purine nucleoside metabolic process |
B | 0042802 | molecular_function | identical protein binding |
B | 0047975 | molecular_function | guanosine phosphorylase activity |
C | 0003824 | molecular_function | catalytic activity |
C | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
C | 0006152 | biological_process | purine nucleoside catabolic process |
C | 0006974 | biological_process | DNA damage response |
C | 0009116 | biological_process | nucleoside metabolic process |
C | 0009164 | biological_process | nucleoside catabolic process |
C | 0016020 | cellular_component | membrane |
C | 0016757 | molecular_function | glycosyltransferase activity |
C | 0016763 | molecular_function | pentosyltransferase activity |
C | 0019686 | biological_process | purine nucleoside interconversion |
C | 0042278 | biological_process | purine nucleoside metabolic process |
C | 0042802 | molecular_function | identical protein binding |
C | 0047975 | molecular_function | guanosine phosphorylase activity |
D | 0003824 | molecular_function | catalytic activity |
D | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006139 | biological_process | nucleobase-containing compound metabolic process |
D | 0006152 | biological_process | purine nucleoside catabolic process |
D | 0006974 | biological_process | DNA damage response |
D | 0009116 | biological_process | nucleoside metabolic process |
D | 0009164 | biological_process | nucleoside catabolic process |
D | 0016020 | cellular_component | membrane |
D | 0016757 | molecular_function | glycosyltransferase activity |
D | 0016763 | molecular_function | pentosyltransferase activity |
D | 0019686 | biological_process | purine nucleoside interconversion |
D | 0042278 | biological_process | purine nucleoside metabolic process |
D | 0042802 | molecular_function | identical protein binding |
D | 0047975 | molecular_function | guanosine phosphorylase activity |
E | 0003824 | molecular_function | catalytic activity |
E | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0006139 | biological_process | nucleobase-containing compound metabolic process |
E | 0006152 | biological_process | purine nucleoside catabolic process |
E | 0006974 | biological_process | DNA damage response |
E | 0009116 | biological_process | nucleoside metabolic process |
E | 0009164 | biological_process | nucleoside catabolic process |
E | 0016020 | cellular_component | membrane |
E | 0016757 | molecular_function | glycosyltransferase activity |
E | 0016763 | molecular_function | pentosyltransferase activity |
E | 0019686 | biological_process | purine nucleoside interconversion |
E | 0042278 | biological_process | purine nucleoside metabolic process |
E | 0042802 | molecular_function | identical protein binding |
E | 0047975 | molecular_function | guanosine phosphorylase activity |
F | 0003824 | molecular_function | catalytic activity |
F | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0006139 | biological_process | nucleobase-containing compound metabolic process |
F | 0006152 | biological_process | purine nucleoside catabolic process |
F | 0006974 | biological_process | DNA damage response |
F | 0009116 | biological_process | nucleoside metabolic process |
F | 0009164 | biological_process | nucleoside catabolic process |
F | 0016020 | cellular_component | membrane |
F | 0016757 | molecular_function | glycosyltransferase activity |
F | 0016763 | molecular_function | pentosyltransferase activity |
F | 0019686 | biological_process | purine nucleoside interconversion |
F | 0042278 | biological_process | purine nucleoside metabolic process |
F | 0042802 | molecular_function | identical protein binding |
F | 0047975 | molecular_function | guanosine phosphorylase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 A 9902 |
Chain | Residue |
A | GLY20 |
A | ARG24 |
A | ARG87 |
A | GLY89 |
A | SER90 |
A | FM29901 |
D | ARG43 |
site_id | AC2 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE FM2 A 9901 |
Chain | Residue |
A | SER90 |
A | CYS91 |
A | GLY92 |
A | PHE159 |
A | VAL178 |
A | GLU179 |
A | MET180 |
A | GLU181 |
A | SER203 |
A | ASP204 |
A | HOH1022 |
A | HOH1082 |
A | PO49902 |
D | HIS4 |
D | ARG43 |
A | MET64 |
A | ARG87 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 B 9904 |
Chain | Residue |
B | GLY20 |
B | ARG24 |
B | ARG87 |
B | GLY89 |
B | SER90 |
B | FM29903 |
E | ARG43 |
site_id | AC4 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE FM2 B 9903 |
Chain | Residue |
B | MET64 |
B | ARG87 |
B | SER90 |
B | CYS91 |
B | GLY92 |
B | PHE159 |
B | VAL178 |
B | GLU179 |
B | MET180 |
B | GLU181 |
B | SER203 |
B | ASP204 |
B | HOH1022 |
B | HOH1109 |
B | PO49904 |
E | HIS4 |
E | ARG43 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 C 9906 |
Chain | Residue |
C | GLY20 |
C | ARG24 |
C | ARG87 |
C | GLY89 |
C | SER90 |
C | FM29905 |
F | ARG43 |
site_id | AC6 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE FM2 C 9905 |
Chain | Residue |
C | MET64 |
C | ARG87 |
C | SER90 |
C | CYS91 |
C | GLY92 |
C | PHE159 |
C | VAL178 |
C | GLU179 |
C | MET180 |
C | GLU181 |
C | SER203 |
C | ASP204 |
C | HOH1026 |
C | HOH1079 |
C | PO49906 |
F | HIS4 |
F | ARG43 |
site_id | AC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PO4 D 9908 |
Chain | Residue |
A | ARG43 |
D | PRO19 |
D | GLY20 |
D | ARG24 |
D | ARG87 |
D | GLY89 |
D | SER90 |
D | FM19907 |
site_id | AC8 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE FM1 D 9907 |
Chain | Residue |
A | HIS4 |
A | ARG43 |
D | ARG87 |
D | SER90 |
D | CYS91 |
D | GLY92 |
D | PHE159 |
D | VAL178 |
D | GLU179 |
D | MET180 |
D | GLU181 |
D | ASP204 |
D | ILE206 |
D | HOH1070 |
D | HOH1098 |
D | PO49908 |
D | HOH9927 |
site_id | AC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 E 9910 |
Chain | Residue |
E | ARG24 |
E | ARG87 |
E | GLY89 |
E | SER90 |
E | FM19909 |
B | ARG43 |
E | GLY20 |
site_id | BC1 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE FM1 E 9909 |
Chain | Residue |
B | HIS4 |
B | ARG43 |
E | MET64 |
E | ARG87 |
E | SER90 |
E | CYS91 |
E | GLY92 |
E | PHE159 |
E | VAL178 |
E | GLU179 |
E | MET180 |
E | GLU181 |
E | ASP204 |
E | ILE206 |
E | HOH1059 |
E | PO49910 |
E | HOH9919 |
site_id | BC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PO4 F 9912 |
Chain | Residue |
C | ARG43 |
F | PRO19 |
F | GLY20 |
F | ARG24 |
F | ARG87 |
F | GLY89 |
F | SER90 |
F | FM19911 |
site_id | BC3 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE FM1 F 9911 |
Chain | Residue |
C | HIS4 |
C | ARG43 |
F | MET64 |
F | ARG87 |
F | SER90 |
F | CYS91 |
F | GLY92 |
F | PHE159 |
F | VAL178 |
F | GLU179 |
F | MET180 |
F | GLU181 |
F | SER203 |
F | ASP204 |
F | HOH1036 |
F | HOH1063 |
F | HOH1064 |
F | PO49912 |
Functional Information from PROSITE/UniProt
site_id | PS01232 |
Number of Residues | 16 |
Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. GhGMGiPScSIytkEL |
Chain | Residue | Details |
A | GLY61-LEU76 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_01627, ECO:0000269|PubMed:30337572 |
Chain | Residue | Details |
A | HIS205 | |
B | HIS205 | |
C | HIS205 | |
D | HIS205 | |
E | HIS205 | |
F | HIS205 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000305|PubMed:30337572, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ |
Chain | Residue | Details |
A | ILE5 | |
B | ILE5 | |
C | ILE5 | |
D | ILE5 | |
E | ILE5 | |
F | ILE5 |
site_id | SWS_FT_FI3 |
Number of Residues | 18 |
Details | BINDING: in other chain => ECO:0000269|PubMed:11786017, ECO:0000269|PubMed:21672603, ECO:0000269|PubMed:30337572, ECO:0007744|PDB:1K9S, ECO:0007744|PDB:3ONV, ECO:0007744|PDB:3OOE, ECO:0007744|PDB:3OOH, ECO:0007744|PDB:3OPV, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ |
Chain | Residue | Details |
A | ASP21 | |
D | ASP21 | |
D | ALA25 | |
D | VAL88 | |
E | ASP21 | |
E | ALA25 | |
E | VAL88 | |
F | ASP21 | |
F | ALA25 | |
F | VAL88 | |
A | ALA25 | |
A | VAL88 | |
B | ASP21 | |
B | ALA25 | |
B | VAL88 | |
C | ASP21 | |
C | ALA25 | |
C | VAL88 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11786017, ECO:0000269|PubMed:21672603, ECO:0000269|PubMed:30337572, ECO:0007744|PDB:1K9S, ECO:0007744|PDB:3ONV, ECO:0007744|PDB:3OOE, ECO:0007744|PDB:3OOH, ECO:0007744|PDB:3OPV, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ |
Chain | Residue | Details |
A | GLY44 | |
B | GLY44 | |
C | GLY44 | |
D | GLY44 | |
E | GLY44 | |
F | GLY44 |
site_id | SWS_FT_FI5 |
Number of Residues | 12 |
Details | BINDING: in other chain => ECO:0000305|PubMed:30337572, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ |
Chain | Residue | Details |
A | MET180 | |
E | ASP204 | |
F | MET180 | |
F | ASP204 | |
A | ASP204 | |
B | MET180 | |
B | ASP204 | |
C | MET180 | |
C | ASP204 | |
D | MET180 | |
D | ASP204 | |
E | MET180 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | SITE: Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_01627, ECO:0000269|PubMed:21672603, ECO:0000269|PubMed:30337572 |
Chain | Residue | Details |
A | GLN218 | |
B | GLN218 | |
C | GLN218 | |
D | GLN218 | |
E | GLN218 | |
F | GLN218 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842 |
Chain | Residue | Details |
A | TYR27 | |
B | TYR27 | |
C | TYR27 | |
D | TYR27 | |
E | TYR27 | |
F | TYR27 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a69 |
Chain | Residue | Details |
A | ASP204 | |
A | ARG217 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a69 |
Chain | Residue | Details |
B | ASP204 | |
B | ARG217 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a69 |
Chain | Residue | Details |
C | ASP204 | |
C | ARG217 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a69 |
Chain | Residue | Details |
D | ASP204 | |
D | ARG217 |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a69 |
Chain | Residue | Details |
E | ASP204 | |
E | ARG217 |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a69 |
Chain | Residue | Details |
F | ASP204 | |
F | ARG217 |
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 375 |
Chain | Residue | Details |
A | ASP21 | electrostatic stabiliser |
A | ALA25 | electrostatic stabiliser |
A | GLY44 | electrostatic stabiliser |
A | VAL88 | electrostatic stabiliser |
A | CYS91 | electrostatic stabiliser |
A | HIS205 | proton shuttle (general acid/base) |
A | GLN218 | enhance reactivity |
site_id | MCSA2 |
Number of Residues | 7 |
Details | M-CSA 375 |
Chain | Residue | Details |
B | ASP21 | electrostatic stabiliser |
B | ALA25 | electrostatic stabiliser |
B | GLY44 | electrostatic stabiliser |
B | VAL88 | electrostatic stabiliser |
B | CYS91 | electrostatic stabiliser |
B | HIS205 | proton shuttle (general acid/base) |
B | GLN218 | enhance reactivity |
site_id | MCSA3 |
Number of Residues | 7 |
Details | M-CSA 375 |
Chain | Residue | Details |
C | ASP21 | electrostatic stabiliser |
C | ALA25 | electrostatic stabiliser |
C | GLY44 | electrostatic stabiliser |
C | VAL88 | electrostatic stabiliser |
C | CYS91 | electrostatic stabiliser |
C | HIS205 | proton shuttle (general acid/base) |
C | GLN218 | enhance reactivity |
site_id | MCSA4 |
Number of Residues | 7 |
Details | M-CSA 375 |
Chain | Residue | Details |
D | ASP21 | electrostatic stabiliser |
D | ALA25 | electrostatic stabiliser |
D | GLY44 | electrostatic stabiliser |
D | VAL88 | electrostatic stabiliser |
D | CYS91 | electrostatic stabiliser |
D | HIS205 | proton shuttle (general acid/base) |
D | GLN218 | enhance reactivity |
site_id | MCSA5 |
Number of Residues | 7 |
Details | M-CSA 375 |
Chain | Residue | Details |
E | ASP21 | electrostatic stabiliser |
E | ALA25 | electrostatic stabiliser |
E | GLY44 | electrostatic stabiliser |
E | VAL88 | electrostatic stabiliser |
E | CYS91 | electrostatic stabiliser |
E | HIS205 | proton shuttle (general acid/base) |
E | GLN218 | enhance reactivity |
site_id | MCSA6 |
Number of Residues | 7 |
Details | M-CSA 375 |
Chain | Residue | Details |
F | ASP21 | electrostatic stabiliser |
F | ALA25 | electrostatic stabiliser |
F | GLY44 | electrostatic stabiliser |
F | VAL88 | electrostatic stabiliser |
F | CYS91 | electrostatic stabiliser |
F | HIS205 | proton shuttle (general acid/base) |
F | GLN218 | enhance reactivity |