1K9K
CRYSTAL STRUCTURE OF CALCIUM BOUND HUMAN S100A6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001726 | cellular_component | ruffle |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005523 | molecular_function | tropomyosin binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005635 | cellular_component | nuclear envelope |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007409 | biological_process | axonogenesis |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0015075 | molecular_function | monoatomic ion transmembrane transporter activity |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0044548 | molecular_function | S100 protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048146 | biological_process | positive regulation of fibroblast proliferation |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0001726 | cellular_component | ruffle |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005523 | molecular_function | tropomyosin binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005634 | cellular_component | nucleus |
| B | 0005635 | cellular_component | nuclear envelope |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007409 | biological_process | axonogenesis |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| B | 0015075 | molecular_function | monoatomic ion transmembrane transporter activity |
| B | 0031012 | cellular_component | extracellular matrix |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0044548 | molecular_function | S100 protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048146 | biological_process | positive regulation of fibroblast proliferation |
| B | 0048306 | molecular_function | calcium-dependent protein binding |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 300 |
| Chain | Residue |
| A | SER20 |
| A | GLU23 |
| A | ASP25 |
| A | THR28 |
| A | GLU33 |
| A | HOH409 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 400 |
| Chain | Residue |
| A | GLU67 |
| A | GLU72 |
| A | HOH401 |
| A | ASP61 |
| A | ASN63 |
| A | ASP65 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 300 |
| Chain | Residue |
| B | SER20 |
| B | GLU23 |
| B | ASP25 |
| B | THR28 |
| B | GLU33 |
| B | HOH402 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 400 |
| Chain | Residue |
| B | ASP61 |
| B | ASN63 |
| B | ASP65 |
| B | GLU67 |
| B | GLU72 |
| B | HOH416 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BME A 100 |
| Chain | Residue |
| A | CYS3 |
| A | HOH452 |
| B | LYS40 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BME B 200 |
| Chain | Residue |
| A | LYS40 |
| B | CYS3 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 70 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 70 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P14069","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
