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1K8U

CRYSTAL STRUCTURE OF CALCIUM-FREE (OR APO) HUMAN S100A6; CYS3MET MUTANT (SELENOMETHIONINE DERIVATIVE)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001726cellular_componentruffle
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005523molecular_functiontropomyosin binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007409biological_processaxonogenesis
A0008270molecular_functionzinc ion binding
A0009898cellular_componentcytoplasmic side of plasma membrane
A0015075molecular_functionmonoatomic ion transmembrane transporter activity
A0034220biological_processmonoatomic ion transmembrane transport
A0042803molecular_functionprotein homodimerization activity
A0044548molecular_functionS100 protein binding
A0046872molecular_functionmetal ion binding
A0048146biological_processpositive regulation of fibroblast proliferation
A0048306molecular_functioncalcium-dependent protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DRNKDQEVNfqEY
ChainResidueDetails
AASP61-TYR73

site_idPS00303
Number of Residues22
DetailsS100_CABP S-100/ICaBP type calcium binding protein signature. LMedLDrnkDqevNFqEYvtFL
ChainResidueDetails
ALEU56-LEU77

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
ATHR28
AGLU33

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448
ChainResidueDetails
AASP61
AASN63
AASP65
AGLU67
AGLU72

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS40

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER46

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P14069
ChainResidueDetails
ALYS47

227344

PDB entries from 2024-11-13

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