1K5K
Homonuclear 1H Nuclear Magnetic Resonance Assignment and Structural Characterization of HIV-1 Tat Mal Protein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001069 | molecular_function | regulatory region RNA binding |
| A | 0001070 | molecular_function | RNA-binding transcription regulator activity |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004865 | molecular_function | protein serine/threonine phosphatase inhibitor activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0019080 | biological_process | viral gene expression |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030332 | molecular_function | cyclin binding |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0032968 | biological_process | positive regulation of transcription elongation by RNA polymerase II |
| A | 0039502 | biological_process | symbiont-mediated suppression of host type I interferon-mediated signaling pathway |
| A | 0039525 | biological_process | symbiont-mediated perturbation of host chromatin organization |
| A | 0039606 | biological_process | symbiont-mediated suppression of host translation initiation |
| A | 0042025 | cellular_component | host cell nucleus |
| A | 0042805 | molecular_function | actinin binding |
| A | 0044196 | cellular_component | host cell nucleolus |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050434 | biological_process | positive regulation of viral transcription |
| A | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| A | 1990970 | molecular_function | trans-activation response element binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 47 |
| Details | Region: {"description":"Transactivation","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 23 |
| Details | Region: {"description":"Interaction with human CREBBP","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 62 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 15 |
| Details | Region: {"description":"Cysteine-rich","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Region: {"description":"Core","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 38 |
| Details | Region: {"description":"Interaction with the host capping enzyme RNGTT","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Nuclear localization signal, RNA-binding (TAR), and protein transduction","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Motif: {"description":"Cell attachment site","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Site: {"description":"Essential for Tat translocation through the endosomal membrane","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; by host PCAF","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine; by host EP300 and GCN5L2","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Asymmetric dimethylarginine; by host PRMT6","evidences":[{"source":"HAMAP-Rule","id":"MF_04079","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
