1K57

OXA 10 class D beta-lactamase at pH 6.0

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0071555	biological_process	cell wall organization
B	0005886	cellular_component	plasma membrane
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0042597	cellular_component	periplasmic space
B	0046677	biological_process	response to antibiotic
B	0071555	biological_process	cell wall organization
C	0005886	cellular_component	plasma membrane
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0042597	cellular_component	periplasmic space
C	0046677	biological_process	response to antibiotic
C	0071555	biological_process	cell wall organization
D	0005886	cellular_component	plasma membrane
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0042597	cellular_component	periplasmic space
D	0046677	biological_process	response to antibiotic
D	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1001

Chain	Residue
A	SER67
A	SER115
A	LYS205
A	THR206
A	GLY207
A	PHE208
A	ARG250
A	HOH1021
A	HOH1091

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1002

Chain	Residue
A	ARG131
A	LYS134
A	TYR135
A	HOH1122

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 B 1003

Chain	Residue
B	SER67
B	SER115
B	LYS205
B	THR206
B	GLY207
B	PHE208
B	ARG250
B	HOH1020
B	HOH1146

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 1004

Chain	Residue
B	LYS95
C	THR206
C	GLY207
C	PHE208
C	ARG250
C	HOH1068
C	HOH1099

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 1005

Chain	Residue
A	LYS95
D	THR206
D	GLY207
D	PHE208
D	ARG250
D	HOH1130
D	HOH1160
D	HOH1171

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1006

Chain	Residue
B	ARG131
B	LYS134
B	TYR135
B	HOH1079
B	HOH1156

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 B 1007

Chain	Residue
B	ARG160

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1008

Chain	Residue
A	MET99
A	LYS100
A	GLN101

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1009

Chain	Residue
C	SER67
C	LYS70
C	SER115
C	ALA116
C	HOH1022

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 1010

Chain	Residue
D	SER67
D	LYS70
D	SER115
D	ALA116
D	VAL117
D	HOH1044
D	HOH1137

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1011

Chain	Residue
B	MET99
B	LYS100
B	GLN101

---

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnAI

Chain	Residue	Details
A	PRO65-ILE75
C	PRO65-ILE75

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"11188693","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E4D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K55","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2RL3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
A	SER67

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
B	SER67

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
C	SER67

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
D	SER67

---