1K56

OXA 10 class D beta-lactamase at pH 6.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
A	0071555	biological_process	cell wall organization
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
B	0071555	biological_process	cell wall organization
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0046677	biological_process	response to antibiotic
C	0071555	biological_process	cell wall organization
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0046677	biological_process	response to antibiotic
D	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 1001

Chain	Residue
A	SER67
A	SER115
A	LYS205
A	THR206
A	GLY207
A	PHE208
A	ARG250
A	HOH1020

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 B 1003

Chain	Residue
B	SER115
B	LYS205
B	THR206
B	GLY207
B	PHE208
B	ARG250
B	HOH1008
B	HOH1169
B	HOH1180
B	SER67

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 1004

Chain	Residue
C	THR206
C	GLY207
C	PHE208
C	ARG250
C	SO41006
C	HOH1063
C	HOH1128

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 1006

Chain	Residue
C	SER67
C	KCX70
C	VAL114
C	SER115
C	ALA116
C	SO41004
C	HOH1114
C	HOH1128

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 1002

Chain	Residue
D	SER67
D	LYS70
D	VAL114
D	SER115
D	ALA116
D	VAL117
D	HOH1021
D	HOH1164

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 1005

Chain	Residue
A	LYS95
D	THR206
D	GLY207
D	PHE208
D	ARG250
D	HOH1184

---

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnAI

Chain	Residue	Details
A	PRO65-ILE75
D	PRO65-ILE75

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Acyl-ester intermediate

Chain	Residue	Details
D	HIS87
B	HIS87
C	HIS87

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
D	TRP225
B	TRP225
C	TRP225

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-carboxylysine => ECO:0000269|PubMed:11188693

Chain	Residue	Details
D	PHE90
B	PHE90
C	PHE90

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
A	SER67

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
B	SER67

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
C	SER67

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
D	SER67

---